换一批
换一批Mannosylated lipid nano-emulsions loaded with lycorine-oleic acid ionic complex for tumor cell-specific delivery
摘要OBJECTIVE:This study was to prepare a marnosylated lycorine lipid nano-emulsion formulation (M-LYC-OA-LNEs) for the aim of achieving tumor targeting delivery of lycorine (LYC).METHOD:Lycorine-oleic acid ionic complex (LYC-OA) was made in order to increase its lipophilicity.M-LYC-OA-LNEs and uncoated lycorine-oleic acid loaded lipid nano-emulsions (LYC-OA-LNEs) were prepared by solvent injection method and characterized by transmission electron microscopy (TEM),particle size,polydispersity index,zeta-potential and entrapment efficiency analysis.
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