换一批摘要It remains an open question when and how the first cell fate decision is made in mammals.Using deep single-cell RNA-seq of matched sister blastomeres, we report highly reproducible inter-blastomere differences among ten 2-cell and five 4-cell mouse embryos.Inter-blastomere gene expression differences dominated between-embryo differences and noises, and were sufficient to cluster sister blastomeres into distinct groups.
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