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换一批Role of receptor interacting protein (RIP)1 on apoptosis-inducing factor-mediated necroptosis during acetaminophen-evoked acute liver failure in mice
摘要Acetaminophen (APAP) overdose induces apoptosis-inducing factor (AIF)-dependent necroptosis,but the mechanism remains obscure.The present study investigated the role of receptor interacting protein (RIP)l,a critical mediator of necroptosis,on AIF-dependent necroptosis during APAP-induced acute liver failure.Mice were intraperitoneally injected with APAP (300 mg/kg).As expected,hepatic RIP 1 was activated as early as 1 h after APAP,which is earlier than APAP-induced hepatic RIP3 upregulation.
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关键词
Acetaminophennecroptosisreceptor-interacting protein (RIP) kinasesapoptosis-inducing factor (AIF)necrostatin-1 (Nec-1)
母体文献
会议名称：
全国卫生毒理学术研讨会
北京
2014年
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发布时间
2016-09-23
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