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摘要A rapid and sensitive UPLC/Q-TOF-MS method has been established for analysis of the constituents in rat serum after oral administration of Fufang Zhenzhu TiaoZhi (FTZ) capsule,an effective compound prescription for treating hyperlipidemia in clinic.The UPLC/MS information of samples was obtained first in FTZ preparation and FTZ-treated rat serum.Mass spectra were acquired in both negative and positive ion modes.36 constituents in rat serum after oral administration of FTZ were detected,including the alkaloids,ginsenosides,pentacyclic triterpenes and their metabolites.These chemicals were identified based on the retention time and mass spectrometry data with those of authentic standards or comparison of the literattres reports.27 prototype components originated from FTZ and 9 were the metabolites of the constituents from FTZ.These results shed a light on the potential active constituents of the complex traditional Chinese medicinal formula.