换一批Paraquat and MPTP induce alterations in the expression profiles of long noncoding RNAs in the substantia nigra of mice: Role of the transcription factor Nrf2
摘要Parkinson's disease (PD) is a common age-related degenerative disease of the central nervous system caused by hereditary, pesticides, metals, and polychlorinated biphenyls.Paraquat (PQ), a widely used herbicide, causes PD.Long noncoding RNAs (lncRNAs) are nonprotein-coding transcripts,expressed in the brain and play irreplaceable roles in neurodegenerative diseases.Nrf2 is an important genetic transcription regulator in oxidative stress.We aimed to discover novel PQ or MPTP-Nrf2-related lncRNAs and explore their associations with PD.
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作者
学术成果认领
关键词
Paraquat1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineNeurodegenerationLncRNANrf2Epigenetic toxicology
医学主题词
百草枯(Paraquat)角色(Role)1-甲基-4-苯基-1,2,3,6-四氢吡啶(1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine)黑质(Substantia Nigra)小鼠(Mice)
会议名称
2016中国毒理学会神经毒理专业委员会学术年会
北京
2016年
主办单位
发布时间
2017-12-04（万方平台首次上网日期，不代表论文的发表时间）
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