检索历史 清除

摘要Although immunotoxic effects of mercury (Hg) on mature immune cells have been widely studied, the influences of Hg on hematopoiesis remain to be defined.The aim of this study was to investigate the effects of Hg on hematopoietic stem and progenitor cells (HSPCs) in the bone marrow (BM) during sub-acute exposure.Herein,we show that methyl Hg (MeHg, 1.25 μM via drinking water) increased the number of granulocyte-macrophage progenitors (GMPs) and decreased the number of common lymphoid progenitors (CLPs), while Hg chloride (HgCl2, 50μM via drinking water) increased the number of GMPs and decreased the numbers of multipotent progenitors (MPPs) and CLPs in B10.S mice.Neither MeHg nor HgC12 affected the numbers of long-term hematopoietic stem cells (LT-HSCs), short-term HSC (ST-HSCs), or common myeloid progenitors (CMPs) in B10.S mice.In accordance with the modulation of Hg on hematopoietic progenitors, MeHg and HgCl2 increased the numbers of mature myeloid cells and decreased the number of B cells in the BM of B10.S mice.Additionally, MeHg did not affect the cell cycling of LT-HSCs, but HgCl2 promoted the cell cycling of LT-HSCs dependent on IFNγ signaling in B10.S mice.In DBA/2 mice, MeHg did not affect HSPCs, but HgCl2 decreased the number of LT-HSCs associated with their suppressed proliferation, and increased the numbers of GMPs and monocytes in the BM.These data indicate Hg modulations on hematopoiesis are strain-dependent.Our study reveals a previously unrecognized hematopoietic toxicity of Hg.