换一批
换一批FZD7 is elevated in CML and regulates sensitivity of CML cells to imatinib in a co-culture system with BMSCs
摘要Objective:To detect the expression of FZD7 in CML CD34+ cells compared to normal CD34+ cells; To investigate the alteration of FZD7 and other Wnt/β-catenin signaling moleculars in CML cells after co-culture with BMSCs derived from both normal and CML bone marrow.To study the effect of FZD7 downregulation on proliferation and imatinib sensitivity in leukemic cells.To reveal the role of FZD7 in mediating a bond between BMSCs and CML cells, providing the basis for molecular targeted therapy.
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作者
学术成果认领
主题词
细胞(Cells)敏感性与特异性(Sensitivity and Specificity)共同培养技术(Coculture Techniques)骨髓(Bone Marrow)减量调节(Down-Regulation)
会议名称
山东省抗癌协会第五次会员代表大会暨山东省第四届肿瘤学术大会
济南
2015年
主办单位
发布时间
2019-01-18
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