Small molecule AX-024 reduces T cell proliferation independently of CD3?/Nck1 interaction, which is governed by a domain swap in the Nck1-SH3.1 domain-论文-万方医学网

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Small molecule AX-024 reduces T cell proliferation independently of CD3?/Nck1 interaction, which is governed by a domain swap in the Nck1-SH3.1 domain

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第一作者： Richter, Kirsten

作者： Richter, Kirsten ^[1] ; Rufer, Arne C. ^[2] ; Muller, Magali ; Burger, Dominique ; Casagrande, Fabio ; Grossenbacher, Tabea ; Huber, Sylwia ; Hug, Melanie N. ; Koldewey, Philipp ; D'Osualdo, Andrea ; Schlatter, Daniel ; Stoll, Theodor ; Rudolph, Markus G.

作者单位： F Hoffmann La Roche Ltd, PRED Pharma Res & Early Dev, Roche Innovat Ctr Basel, Therapeut Modal ^[1] F Hoffmann La Roche Ltd, I2O Dis Translat Area, Grenzacherstr 124, CH-4070 Basel, Switzerland ^[2]

关键词 adaptor protein crystal structure T-cell receptor (TCR)protein drug interaction cell proliferation structure-function protein structure nuclear magnetic resonance (NMR)analytical ultracentrifugation surface plasmon resonance (SPR)

发布时间 2022-09-11

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Small molecule AX-024 reduces T cell proliferation independently of CD3?/Nck1 interaction, which is governed by a domain swap in the Nck1-SH3.1 domain

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Small molecule AX-024 reduces T cell proliferation independently of CD3?/Nck1 interaction, which is governed by a domain swap in the Nck1-SH3.1 domain

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