Discovery of (7 R)-14-Cyclohexyl-7-{[2-(dimethylamino)ethyl](methyl) amino}-7,8-dihydro-6 H -indolo[1,2- e ][1,5]benzoxazocine-11-carboxylic Acid (MK-3281), a potent and orally bioavailable finger-loop inhibitor of the hepatitis C virus NS5B polymerase

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作者： Narjes, F. ^[1] ; Crescenzi, B. ^[2] ; Ferrara, M. ; Habermann, J. ; Colarusso, S. ; Del Rosario Rico Ferreira, M. ; Stansfield, I. ; MacKay, A.C. ; Conte, I. ; Ercolani, C. ; Zaramella, S. ; Palumbi, M.-C. ; Meuleman, P. ; Leroux-Roels, G. ; Giuliano, C. ; Fiore, F. ; Di Marco, S. ; Baiocco, P. ; Koch, U. ; Migliaccio, G. ; Altamura, S. ; Laufer, R. ; De Francesco, R. ; Rowley, M.

作者单位： Istituto di Ricerche di Biologia Molecolare, P. Angeletti SpA (Merck Research Laboratories, Rome), Via Pontina Km 30, 600, I-00040 Pomezia, Italy ^[1] Center for Vaccinology, Ghent University and Hospital, De Pintelaan 185, B-9000 Gent, Belgium ^[2]

发布时间 2013-11-20

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Journal of Medicinal Chemistry

2011年54卷1期

289-301页

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Discovery of (7 R)-14-Cyclohexyl-7-{[2-(dimethylamino)ethyl](methyl) amino}-7,8-dihydro-6 H -indolo[1,2- e ][1,5]benzoxazocine-11-carboxylic Acid (MK-3281), a potent and orally bioavailable finger-loop inhibitor of the hepatitis C virus NS5B polymerase

Journal of Medicinal Chemistry

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Journal of Medicinal Chemistry

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Discovery of (7 R)-14-Cyclohexyl-7-{[2-(dimethylamino)ethyl](methyl) amino}-7,8-dihydro-6 H -indolo[1,2- e ][1,5]benzoxazocine-11-carboxylic Acid (MK-3281), a potent and orally bioavailable finger-loop inhibitor of the hepatitis C virus NS5B polymerase

Journal of Medicinal Chemistry

相似文献

Journal of Medicinal Chemistry

相关期刊

检索历史清除