Lead optimization of 2-(piperidin-3-yl)-1H-benzimidazoles: Identification of 2-morpholin- and 2-thiomorpholin-2-yl-1H-benzimidazoles as selective and CNS penetrating H 1-antihistamines for insomnia

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作者： Ravula,S.B. ^[1] ; Yu,J. ; Tran,J.A. ; Arellano,M. ; Tucci,F.C. ; Moree,W.J. ; Li,B.-F. ; Petroski,R.E. ; Wen,J. ; Malany,S. ; Hoare,S.R.J. ; Madan,A. ; Crowe,P.D. ; Beaton,G.

作者单位： Neurocrine Biosciences, 12780 El Camino Real, San Diego, CA 92130, United States ^[1]

关键词 Benzimidazole CNS penetration H 1-antihistamines Insomnia Lead optimization Structure-activity relationship (SAR)

发布时间 2013-11-20

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Bioorganic and Medicinal Chemistry Letters

2012年22卷1期

421-426页

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Lead optimization of 2-(piperidin-3-yl)-1H-benzimidazoles: Identification of 2-morpholin- and 2-thiomorpholin-2-yl-1H-benzimidazoles as selective and CNS penetrating H 1-antihistamines for insomnia

Bioorganic and Medicinal Chemistry Letters

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Bioorganic and Medicinal Chemistry Letters

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Lead optimization of 2-(piperidin-3-yl)-1H-benzimidazoles: Identification of 2-morpholin- and 2-thiomorpholin-2-yl-1H-benzimidazoles as selective and CNS penetrating H 1-antihistamines for insomnia

Bioorganic and Medicinal Chemistry Letters

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Bioorganic and Medicinal Chemistry Letters

相关期刊

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