Structure-guided design of aminopyrimidine amides as potent, selective inhibitors of lymphocyte specific kinase: Synthesis, structure-activity relationships, and inhibition of in vivo T cell activation

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作者： DiMauro EF ^[1] ; Newcomb J ^[2] ; Nunes JJ ^[3] ; Bemis JE ^[4] ; Boucher C ^[5] ; Chai L ^[6] ; Chaffee SC ^[7] ; Deak HL ^[8] ; Epstein LF ; Faust T

作者单位： Amgen Inc, Dept Pharmaceut, Thousand Oaks, CA 91320 USA ^[1] Amgen Inc, Dept HTS & Mol Pharmacol, Cambridge, MA 02139 USA ^[2] Amgen Inc, Dept HTS & Mol Pharmacol, Thousand Oaks, CA 91320 USA ^[3] Amgen Inc, Dept Mol Struct, Cambridge, MA 02139 USA ^[4] Amgen Inc, Dept Pharmacokinet & Drug Metab, Thousand Oaks, CA 91320 USA ^[5] syk.uit.no ^[6] Amgen Inc, Dept Inflammat, Thousand Oaks, CA 91320 USA ^[7] Amgen Inc, Dept Med Chem, Cambridge, MA 02139 USA ^[8]

关键词 SRC-FAMILY KINASES SMALL-MOLECULE INHIBITOR LYN-DEFICIENT MICE GROWTH-FACTOR VEGF TYROSINE KINASE ANTIINFLAMMATORY ACTIVITY P56(LCK) INHIBITORS ALLOGRAFT-REJECTION ANTIGEN RECEPTOR ANGIOGENESIS INHIBITORS

发布时间 2013-11-20

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