GDC-9545 (Giredestrant): A Potent and Orally Bioavailable Selective Estrogen Receptor Antagonist and Degrader with an Exceptional Preclinical Profile for ER plus Breast Cancer

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作者： Liang, Jun ^[1] ; Zbieg, Jason R. ^[2] ; Blake, Robert A. ^[3] ; Chang, Jae H. ; Daly, Stephen ; DiPasquale, Antonio G. ; Friedman, Lori S. ; Gelzleichter, Thomas ; Gill, Matthew ; Giltnane, Jennifer M. ; Goodacre, Simon ; Guan, Jane ; Hartman, Steven J. ; Ingalla, Ellen Rei ; Kategaya, Lorn ; Kiefer, James R. ; Kleinheinz, Tracy ; Labadie, Sharada S. ; Lai, Tommy ; Li, Jun ; Liao, Jiangpeng ; Liu, Zhiguo ; Mody, Vidhi ; McLean, Neville ; Metcalfe, Ciara ; Nannini, Michelle A. ; Oeh, Jason ; O'Rourke, Martin G. ; Ortwine, Daniel F. ; Ran, Yingqing ; Ray, Nicholas C. ; Roussel, Fabien ; Sambrone, Amy ; Sampath, Deepak ; Schutt, Leah K. ; Vinogradova, Maia ; Wai, John ; Wang, Tao ; Wertz, Ingrid E. ; White, Jonathan R. ; Yeap, Siew Kuen ; Young, Amy ; Zhang, Birong ; Zheng, Xiaoping ; Zhou, Wei ; Zhong, Yu ; Wang, Xiaojing

作者单位： WuXi AppTec Co Ltd, Shanghai 200131, Peoples R China ^[1] Genentech Inc, San Francisco, CA 94080 USA ^[2] Charles River Discovery Res Serv UK Ltd, Harlow CM19 5TR, Essex, England ^[3]

发布时间 2022-01-30

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Journal of Medicinal Chemistry

2021年64卷16期

11841-11856页

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GDC-9545 (Giredestrant): A Potent and Orally Bioavailable Selective Estrogen Receptor Antagonist and Degrader with an Exceptional Preclinical Profile for ER plus Breast Cancer

Journal of Medicinal Chemistry

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Journal of Medicinal Chemistry

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GDC-9545 (Giredestrant): A Potent and Orally Bioavailable Selective Estrogen Receptor Antagonist and Degrader with an Exceptional Preclinical Profile for ER plus Breast Cancer

Journal of Medicinal Chemistry

相似文献

Journal of Medicinal Chemistry

相关期刊

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