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Overcoming the Hydrolytic Lability of a Reaction Intermediate in Production of Protein/Drug Conjugates: Conjugation of an Acyclic Nucleoside Phosphonate to a Model Carrier Protein

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第一作者： Xu, Shengsheng

作者： Xu, Shengsheng ^[1] ; Kaltashov, Igor A.

作者单位： Univ Massachusetts Amherst, Dept Chem, 240 Thatcher Way,Life Sci Labs N369, Amherst, MA 01003 USA ^[1]

关键词 human immunodeficiency virus (HIV)antiretroviral therapy adefovir protein/drug conjugate electrospray ionization mass spectrometry (ESI MS)ion exchange chromatography LC/MS top-down MS/MS

发布时间 2018-06-23

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Molecular pharmaceutics

2017年14卷8期

2843-2851页

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Molecular pharmaceutics

2017年14卷8期

2843-2851页

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Overcoming the Hydrolytic Lability of a Reaction Intermediate in Production of Protein/Drug Conjugates: Conjugation of an Acyclic Nucleoside Phosphonate to a Model Carrier Protein

Molecular pharmaceutics

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Overcoming the Hydrolytic Lability of a Reaction Intermediate in Production of Protein/Drug Conjugates: Conjugation of an Acyclic Nucleoside Phosphonate to a Model Carrier Protein

Molecular pharmaceutics

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Molecular pharmaceutics

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