ACAT-selective and nonselective DGAT1 inhibition: Adrenocortical effects - A cross-species comparison

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作者： Floettmann,J.E. ^[1] ; Buckett,L.K. ^[2] ; Turnbull,A.V. ^[3] ; Smith,T. ^[4] ; Hallberg,C. ; Birch,A. ; Lees,D. ; Jones,H.B.

作者单位： Global Safety Assessment, AstraZeneca, Mereside, Alderley Park, Macclesfield Cheshire SK10 4TG ^[1] Cyprotex Discovery Ltd., Macclesfield, United Kingdom ^[2] Cardiovascular and Gastrointestinal Research Department, AstraZeneca, Alderley Park, Macclesfield ^[3] Cardiovascular and Gastrointestinal Research Department, AstraZeneca, M?lndal, Sweden ^[4]

关键词 ACAT1 acyl-coenzyme A:Cholesterol acyltransferase adrenal toxicity adrenocortical degeneration animal models DGAT1 mechanisms of toxicity

发布时间 2013-12-19

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