Generation of antibody- and B cell-deficient pigs by targeted disruption of the J-region gene segment of the heavy chain locus

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作者： M. Mendicino ^[1] ; J. Ramsoondar ^[2] ; C. Phelps ^[3] ; T. Vaught ^[4] ; S. Ball ; T. LeRoith ; J. Monahan ; S. Chen ; A. Dandro ; J. Boone ; P. Jobst ; A. Vance ; N. Wertz ; Z. Bergman ; X-Z. Sun ; I. Polejaeva ; J. Butler ; Y. Dai ; D. Ayares ; K. Wells

作者单位： Department of Biomedical Sciences and Pathobiology, Virginia-Maryland Regional College of Veterinary Medicine, Duck Pond Drive (0442), Blacksburg, VA 24061, USA ^[1] Division of Animal Sciences, University of Missouri, 920 East Campus Drive, Columbia, MO 65211, USA ^[2] Revivicor, Inc., 1700 Kraft Drive, Blacksburg, VA 24060, USA ^[3] Department of Microbiology and Interdisciplinary Immunology Program, University of Iowa, 3-550 Bowen Science Building, Iowa City, IA 52242, USA ^[4]

关键词 Genetically engineered animal model Immunoglobulin heavy chain locus B cell and antibody deficiency Somatic cell nuclear transfer Humoral versus cellular immunity Human polyclonal antibody

发布时间 2013-11-20

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