Stable expansion of high-grade serous ovarian cancer organoids requires a low-Wnt environment

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作者： Hoffmann, Karen ^[1] ; Berger, Hilmar ^[2] ; Kulbe, Hagen ^[3] ; Thillainadarasan, Sukanija ^[4] ; Mollenkopf, Hans-Joachim ^[5] ; Zemojtel, Tomasz ; Taube, Eliane ; Darb-Esfahani, Silvia ; Mangler, Mandy ; Sehouli, Jalid ; Chekerov, Radoslav ; Braicu, Elena, I ; Meyer, Thomas F. ; Kessler, Mirjana

作者单位： Charite, BIH Genom Core Unit, Campus Virchow Klinikum, Berlin, Germany ^[1] Charite, Dept Gynecol, Campus Virchow Klinikum, Berlin, Germany ^[2] Vivantes Auguste Viktoria Klinikum, Dept Gynecol, Berlin, Germany ^[3] Charite, Dept Pathol, Campus Charite, Berlin, Germany ^[4] Max Planck Inst Infect Biol, Dept Mol Biol, Berlin, Germany ^[5]

关键词 BMP signaling patient-derived HGSOC organoids stemness tumor suppressor knockdown Wnt signaling

发布时间 2021-02-03

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