作者单位:Oswaldo Cruz Foundation (FIOCRUZ), Bio-Manguinhos, Viral Vaccine Program, Avenida Brasil 4365, 21045-900 Rio de Janeiro/RJ, Brazil[1]Federal University of Rio de Janeiro, COPPE, Cell Culture Engineering Laboratory, Cx. Postal 68502, 21941-972 Rio de Janeiro/RJ, Brazil[2]