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Loss-of-function mutations in APOC3, triglycerides, and coronary disease

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第一作者: Crosby,J.
作者单位: William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen [1] Department of Biostatistics, Boston University School of Public Health, Boston, MA, United States [2] Department of Epidemiology, University of North Carolina, Chapel Hill, NC, United States [3] German Center for Cardiovascular Research, Munich, Germany, Helmholtz Zentrum München, German [4] Department of Biostatistics, University of Michigan, Ann Arbor, MI, United States, Center for [5] Deutsches Herzzentrum München, Technische Universit?t München, Munich, Germany, Medizinische Klinik [6] Departments of Medicine, Epidemiology, and Health Services, University of Washington, Seattle, WA [7] Department of Computational Medicine and Bioinformatics, University of Michigan, New York, NY [8] Institute of Human Genetics, University of Bonn, Bonn, Germany [9] Department of Genome Sciences, Cardiovascular Health Research Unit, University of Washington [10] Deutsches Herzzentrum München, Technische Universit?t München, Munich, Germany [11] Department of Biostatistics, Bioinformatics, and Systems Biology, University of Texas Graduate [12] Department of Cardiovascular Sciences, University of Leicester, National Institute for Health [13] Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States [14] Department of Epidemiology, University of North Carolina, Chapel Hill, NC, United States, Carolina [15] Medical Research Institute, Ninewells Hospital and Medical School, Dundee, United Kingdom [16] Nutrition and Genomics Laboratory, Jean Mayer-USDA Human Nutrition Research Center on Aging, Tufts [17] Institut für Medizinische Biometrie und Statistik, Universit?t zu Lübeck, Lübeck, Germany [18] Division of Cardiology, George Washington University School of Medicine and Health Sciences [19] Dipartimento di Biotecnologie Mediche e Medicina Traslazionale, Università degli Studi di Milano [20] Department of Medicine, Skellefte? Hospital, Skellefte?, Sweden, Department of Public Health and [21] Division of Cardiology, Ospedale Niguarda, Milan, Italy [22] Departments of Epidemiology and Medicine, College of Public Health, University of Iowa, Ames, IA [23] Departments of Pathology and Biochemistry, University of Vermont College of Medicine, Burlington [24] Institut für Integrative und Experimentelle Genomik, Universit?t zu Lübeck, Lübeck, Germany, DZHK [25] Center for Human Genetic Research, Cardiovascular Research Center, Massachusetts General Hospital [26] Radcliffe Department of Medicine, Wellcome Trust Centre for Human Genetics, University of Oxford [27] Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, United States [28] Merck Sharp and Dohme, Boston, MA, United States [29] Department of Clinical Sciences, Diabetes and Endocrinology, Lund University, University Hospital [30] National Heart, Lung and Blood Institute Framingham Heart Study, Framingham, MA, United States [31] Nord-Tr?ndelag Health Study (HUNT) Research Center, Department of Public Health and General [32] Department of Epidemiology, Cardiovascular Health Research Unit, University of Washington, Seattle [33] Department of Biostatistics, University of North Carolina, Chapel Hill, NC, United States [34] Division of Cardiology, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy [35] Department of Genetics, University of North Carolina, Chapel Hill, NC, United States [36] Institute of Epidemiology and Biobank Popgen, Christian-Albrechts University Kiel, Kiel, Germany [37] Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New [38] Baylor College of Medicine, Houston, TX, United States, Methodist DeBakey Heart and Vascular Center [39] Division of Cardiology, University of Ottawa Heart Institute, Ottawa, ON, Canada [40] Center for Public Health Genomics, University of Virginia, Charlottesville, VA, United States [41] Department of Biostatistics, University of Michigan, Ann Arbor, MI, United States [42] Department of Internal Medicine, University of Michigan, New York, NY, United States, Department of [43] School of Public Health, University of Wisconsin-Milwaukee, Milwaukee, WI, United States [44] Institute of Human Genetics, Technische Universit?t München, Munich, Germany [45] Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital [46] Division of Epidemiology, School of Medicine, University of Leeds, Leeds, United Kingdom [47] Department of Medicine, Stanford University School of Medicine, Stanford, CA, United States [48] University of Verona School of Medicine, Department of Medicine, Verona, Italy [49] Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, United [50] Department of Cardiology, West German Heart Center, Essen, Germany [51] Department of Clinical Science, Lund University, University Hospital Malm?, Malm?, Sweden [52] Department of Clinical Sciences, Lund University, University Hospital Malm?, Malm?, Sweden [53] Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS [54] Department of Medicine, Division of Statistical Genomics, Washington University School of Medicine [55]
发布时间 2014-09-04
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The New England journal of medicine

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