Oral Immunization with Nontoxigenic Clostridium difficile Strains Expressing Chimeric Fragments of TcdA and TcdB Elicits Protective Immunity against C. difficile Infection in Both Mice and Hamsters

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作者： Wang, Yuanguo ^[1] ; Wang, Shaohui ^[2] ; Bouillaut, Laurent ^[3] ; Li, Chunhui ^[4] ; Duan, Zhibian ^[5] ; Zhang, Keshan ; Ju, Xianghong ; Tzipori, Saul ; Sonenshein, Abraham L. ; Sun, Xingmin

作者单位： Univ S Florida, Morsani Sch Med, Dept Mol Med, Tampa, FL 33620 USA ^[1] Tufts Univ, Sch Med, Dept Mol Biol & Microbiol, Boston, MA 02111 USA ^[2] Chinese Acad Agr Sci, Lanzhou Vet Res Inst, State Key Lab Vet Etiol Biol, Natl Foot & Mouth Dis ^[3] Tufts Univ, Sch Vet Med, Dept Infect Dis & Global Hlth, 200 Westboro Rd, North Grafton, MA 01536 USA ^[4] Guangdong Ocean Univ, Dept Vet Med, Zhanjiang, Peoples R China ^[5]

关键词 Clostridium difficile infection oral immunization vaccine nontoxigenic

发布时间 2019-05-25

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