In vitro-in silico-based prediction of inter-individual and inter-ethnic variations in the dose-dependent cardiotoxicity of R- and S-methadone in humans-论文-万方医学网

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In vitro-in silico-based prediction of inter-individual and inter-ethnic variations in the dose-dependent cardiotoxicity of R- and S-methadone in humans

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第一作者： Shi, Miaoying

作者： Shi, Miaoying ^[1] ; Dong, Yumeng ^[2] ; Bouwmeester, Hans ; Rietjens, Ivonne M. C. M. ; Strikwold, Marije

作者单位： Div Toxicol,Wageningen Univ ^[1] Van Hall Larenstein Univ Appl Sci ^[2]

关键词 Methadone Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM)Quantitative in vitro to in vivo extrapolation (QIVIVE)Inter-individual differences Monte Carlo simulation Physiologically based kinetic (PBK) modelling New approach methodologies (NAM)HUMAN LIVER-MICROSOMES CYTOCHROME P4502B6 STEADY-STATE STEREOSELECTIVE METABOLISM N-DEMETHYLATION DRUG CLEARANCE PHARMACOKINETICS VARIABILITY CYP2B6 EXTRAPOLATION

发布时间 2022-10-05

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In vitro-in silico-based prediction of inter-individual and inter-ethnic variations in the dose-dependent cardiotoxicity of R- and S-methadone in humans

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In vitro-in silico-based prediction of inter-individual and inter-ethnic variations in the dose-dependent cardiotoxicity of R- and S-methadone in humans

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