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High-sensitivity quantitation of a Nanobody (R) in plasma by single-cartridge multidimensional SPE and ultra-performance LC-MS/MS

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第一作者： Bronsema, Kees J.

作者： Bronsema, Kees J. ^[1] ; Bischoff, Rainer ^[2] ; Bouche, Marie-Paule ^[3] ; Mortier, Kjell ; van de Merbel, Nico C.

作者单位： PRA Hlth Sci, Early Dev Serv, Bioanalyt Lab, NL-9405 BJ Assen, Netherlands ^[1] Ablynx NV, B-9052 Ghent, Belgium ^[2] Univ Groningen, Dept Pharm, NL-9713 AV Groningen, Netherlands ^[3]

关键词 antibody-free biopharmaceutical enzymatic digestion high sensitivity LC-MS MS multidimensional SPE Nanobody oxygen exchange internal standard

发布时间 2015-09-17

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Bioanalysis

2015年7卷1期

53-64页

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Bioanalysis

2015年7卷1期

53-64页

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High-sensitivity quantitation of a Nanobody (R) in plasma by single-cartridge multidimensional SPE and ultra-performance LC-MS/MS

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High-sensitivity quantitation of a Nanobody (R) in plasma by single-cartridge multidimensional SPE and ultra-performance LC-MS/MS

Bioanalysis

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Bioanalysis

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