首页> Journal of Medicinal Chemistry> Multiparameter Optimization in CNS Drug Discovery: Design of Pyrimido[4,5-d]azepines as Potent 5-Hydroxytryptamine 2C (5-HT_(2C)) Receptor Agonists with Exquisite Functional Selectivity over 5-HT_(2A) and 5-HT_(2B) Receptors

Multiparameter Optimization in CNS Drug Discovery: Design of Pyrimido[4,5-d]azepines as Potent 5-Hydroxytryptamine 2C (5-HT_(2C)) Receptor Agonists with Exquisite Functional Selectivity over 5-HT_(2A) and 5-HT_(2B) Receptors

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作者： R. Ian Storer ^[1] ; Paul E. Brennan ^[2] ; Alan D. Brown ^[3] ; Peter J. Bungay ^[4] ; Kelly M. Conlon ^[5] ; Matthew S. Corbett ; Robert P. DePianta ; Paul V. Fish ; Alexander Heifetz ; Danny K. H. Ho ; Alan S. Jessiman ; Gordon McMurray ; Cesar Augusto F. de Oliveira ; Lee R. Roberts ; James A. Root ; Veerabahu Shanmugasundaram ; Michael J. Shapiro ; Melanie Skerten ; Dominique Westbrook ; Simon Wheeler ; Gavin A. Whitlock ; John Wright

作者单位： Discovery Biology, Sandwich Laboratories, Pfizer Global ^[1] Discovery Chemistry, Sandwich Laboratories, Pfizer Global ^[2] Pharmacokinetics, Dynamics and Metabolism, Sandwich Laboratories, Pfizer Global Research and Development, Ramsgate Road, Sandwich, Kent CT13 9NJ, United Kingdom ^[3] Evotec (UK) Ltd., 114 Innovation Drive, Milton Park, Abingdon, Oxfordshire, OX14 4RZ, United Kingdom ^[4] Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States ^[5]

关键词 Multiparameter Optimization CNS Drug Discovery Exquisite Functional Selectivity

发布时间 2014-09-17

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