Intranasal insulin therapy reverses hippocampal dendritic injury and cognitive impairment in a model of HIV-associated neurocognitive disorders in EcoHIV-infected mice

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作者： Kim, Boe-Hyun ^[1] ; Kelschenbach, Jennifer ^[2] ; Borjabad, Alejandra ^[3] ; Hadas, Eran ; He, Hongxia ; Potash, Mary Jane ; Nedelcovych, Michael T. ; Rais, Rana ; Haughey, Norman J. ; McArthur, Justin C. ; Slusher, Barbara S. ; Volsky, David J.

作者单位： Johns Hopkins Sch Med, Dept Neurol, Baltimore, MD USA ^[1] Icahn Sch Med Mt Sinai, Dept Med, Div Infect Dis, New York, NY 10029 USA ^[2] Johns Hopkins Sch Med, Johns Hopkins Drug Discovery Program, Baltimore, MD USA ^[3]

关键词 EcoHIV fear conditioning HIV-associated neurocognitive impairment insulin intranasal insulin therapy mouse models quantitative PCR radial arm water maze synaptodendritic injury working memory

发布时间 2019-12-11

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