换一批Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits
第一作者：
Evangelou, Evangelos
作者：
Evangelou, Evangelos [1]
;
Warren, Helen R. [2]
;
Mosen-Ansorena, David [3]
;
Mifsu, Borbala [4]
;
Pazoki, Raha [5]
;
Gao, He [6]
;
Ntritsos, Georgios [7]
;
Dimou, Niki [8]
;
Cabrer, Claudia P. [9]
;
Karaman, Ibrahim [10]
;
Ng, FuLiang [11]
;
Evangelou, Marina [12]
;
Witkowska, Katarzyna [13]
;
Tzanis, Evan [14]
;
Hellwege, Jacklyn N. [15]
;
Giri, Ayush [16]
;
Edwards, Digna R. Velez [17]
;
Sun, Yan, V [18]
;
Cho, Kelly [19]
;
Gaziano, J. Michael [20]
;
Wilson, Peter W. F. [21]
;
Tsao, Philip S. [22]
;
Kovesdy, Csaba P. [23]
;
Esko, Tonu [24]
;
Magi, Reedik [25]
;
Milani, Lili [26]
;
Almgren, Peter [27]
;
Boutin, Thibaud [28]
;
Debette, Stephanie [29]
;
Ding, Jun [30]
;
Giulianini, Franco [31]
;
Holliday, Elizabeth G. [32]
;
Jackson, Anne U. [33]
;
Li-Gao, Ruifang [34]
;
Lin, Wei-Yu [35]
;
Luan, Jian'an [36]
;
Mangino, Massimo [37]
;
Oldmeadow, Christopher [38]
;
Prins, Bram Peter [39]
;
Qian, Yong [40]
;
Sargurupremraj, Muralidharan [41]
;
Shah, Nabi [42]
;
Surendran, Praveen [43]
;
Theriault, Sebastien [44]
;
Verweij, Niek [45]
;
Willems, Sara M. [46]
;
Zhao, Jing-Hua [47]
;
Amouyel, Philippe [48]
;
Connell, John [49]
;
de Mutsert, Renee [50]
;
Doney, Alex S. F. [51]
;
Farrall, Martin [52]
;
Menni, Cristina [53]
;
Morris, Andrew D. [54]
;
Noordam, Raymond [55]
;
Pare, Guillaume [56]
;
Poulter, Neil R. [57]
;
Shields, Denis C. [58]
;
Stanton, Alice [59]
;
Thom, Simon [60]
;
Abecasis, Goncalo [61]
;
Amin, Najaf [62]
;
Arking, Dan E. [63]
;
Ayers, Kristin L. [64]
;
Barbieri, Caterina M. [65]
;
Batini, Chiara [66]
;
Bis, Joshua C. [67]
;
Blake, Tineka [68]
;
Bochud, Murielle [69]
;
Boehnke, Michael [70]
;
Boerwinkle, Eric [71]
;
Boomsma, Dorret, I [72]
;
Bottinger, Erwin P. [73]
;
Braund, Peter S. [74]
;
Brumat, Marco [75]
;
Campbell, Archie [76]
;
Campbell, Harry [77]
;
Chakravarti, Aravinda [78]
;
Chambers, John C. [79]
;
Chauhan, Ganesh [80]
;
Ciullo, Marina [81]
;
Cocca, Massimiliano [82]
;
Collins, Francis [83]
;
Cordell, Heather J. [84]
;
Davies, Gail [85]
;
de Borst, Martin H. [86]
;
de Geus, Eco J. [87]
;
Deary, Ian J. [88]
;
Deelen, Joris [89]
;
Del Greco, Fabiola M. [90]
;
Demirkale, Cumhur Yusuf [91]
;
Doerr, Marcus [92]
;
Ehret, Georg B. [93]
;
Elosua, Roberto [94]
;
Enroth, Stefan [95]
;
Erzurumluoglu, A. Mesut [96]
;
Ferreira, Teresa [97]
;
Franberg, Mattias [98]
;
Franco, Oscar H. [99]
;
Gandin, Ilaria [100]
;
Gasparini, Paolo [101]
;
Giedraitis, Vilmantas [102]
;
Gieger, Christian [103]
;
Girotto, Giorgia [104]
;
Goel, Anuj [105]
;
Gow, Alan J. [106]
;
Gudnason, Vilmundur [107]
;
Guo, Xiuqing [108]
;
Gyllensten, Ulf [109]
;
Hamsten, Anders [110]
;
Harris, Tamara B. [111]
;
Harris, Sarah E. [112]
;
Hartman, Catharina A. [113]
;
Havulinna, Aki S. [114]
;
Hicks, Andrew A. [115]
;
Hofer, Edith [116]
;
Hofman, Albert [117]
;
Hottenga, Jouke-Jan [118]
;
Huffman, Jennifer E. [119]
;
Hwang, Shih-Jen [120]
;
Ingelsson, Erik [121]
;
James, Alan [122]
;
Jansen, Rick [123]
;
Jarvelin, Marjo-Riitta [124]
;
Joehanes, Roby [125]
;
Johansson, Asa [126]
;
Johnson, Andrew D. ;
Joshi, Peter K. ;
Jousilahti, Pekka ;
Jukema, J. Wouter ;
Jula, Antti ;
Kahonen, Mika ;
Kathiresan, Sekar ;
Keavney, Bernard D. ;
Khaw, Kay-Tee ;
Knekt, Paul ;
Knight, Joanne ;
Kolcic, Ivana ;
Kooner, Jaspal S. ;
Koskinen, Seppo ;
Kristiansson, Kati ;
Kutalik, Zoltan ;
Laan, Maris ;
Larson, Marty ;
Launer, Lenore J. ;
Lehne, Benjamin ;
Lehtimaki, Terho ;
Liewald, David C. M. ;
Lin, Li ;
Lind, Lars ;
Lindgren, Cecilia M. ;
Liu, YongMei ;
Loos, Ruth J. F. ;
Lopez, Lorna M. ;
Lu, Yingchang ;
Lyytikainen, Leo-Pekka ;
Mahajan, Anubha ;
Mamasoula, Chrysovalanto ;
Marrugat, Jaume ;
Marten, Jonathan ;
Milaneschi, Yuri ;
Morgan, Anna ;
Morris, Andrew P. ;
Morrison, Alanna C. ;
Munson, Peter J. ;
Nalls, Mike A. ;
Nandakumar, Priyanka ;
Nelson, Christopher P. ;
Niiranen, Teemu ;
Nolte, Ilja M. ;
Nutile, Teresa ;
Oldehinkel, Albertine J. ;
Oostra, Ben A. ;
O'Reilly, Paul F. ;
Org, Elin ;
Padmanabhan, Sandosh ;
Palmas, Walter ;
Palotie, Aarno ;
Pattie, Alison ;
Penninx, Brenda W. J. H. ;
Perola, Markus ;
Peters, Annette ;
Polasek, Ozren ;
Pramstaller, Peter P. ;
Nguyen, Quang Tri ;
Raitakari, Olli T. ;
Ren, Meixia ;
Rettig, Rainer ;
Rice, Kenneth ;
Ridker, Paul M. ;
Ried, Janina S. ;
Riese, Harriette ;
Ripatti, Samuli ;
Robino, Antonietta ;
Rose, Lynda M. ;
Rotter, Jerome, I ;
Rudan, Igor ;
Ruggiero, Daniela ;
Saba, Yasaman ;
Sala, Cinzia F. ;
Salomaa, Veikko ;
Samani, Nilesh J. ;
Sarin, Antti-Pekka ;
Schmidt, Reinhold ;
Schmidt, Helena ;
Shrine, Nick ;
Siscovick, David ;
Smith, Albert, V ;
Snieder, Harold ;
Sober, Siim ;
Sorice, Rossella ;
Starr, John M. ;
Stott, David J. ;
Strachan, David P. ;
Strawbridge, Rona J. ;
Sundstrom, Johan ;
Swertz, Morris A. ;
Taylor, Kent D. ;
Teumer, Alexander ;
Tobin, Martin D. ;
Tomaszewski, Maciej ;
Toniolo, Daniela ;
Traglia, Michela ;
Trompet, Stella ;
Tuomilehto, Jaakko ;
Tzourio, Christophe ;
Uitterlinden, Andre G. ;
Vaez, Ahmad ;
van der Most, Peter J. ;
van Duijn, Cornelia M. ;
Vergnaud, Anne-Claire ;
Verwoert, Germaine C. ;
Vitart, Veronique ;
Voelker, Uwe ;
Vollenweider, Peter ;
Vuckovic, Dragana ;
Watkins, Hugh ;
Wild, Sarah H. ;
Willemsen, Gonneke ;
Wilson, James F. ;
Wright, Alan F. ;
Yao, Jie ;
Zemunik, Tatijana ;
Zhang, Weihua ;
Attia, John R. ;
Butterworth, Adam S. ;
Chasman, Daniell ;
Conen, David ;
Cucca, Francesco ;
Danesh, John ;
Hayward, Caroline ;
Howson, Joanna M. M. ;
Laakso, Markku ;
Lakatta, Edward G. ;
Langenberg, Claudia ;
Melander, Olle ;
Mook-Kanamori, Dennis O. ;
Palmer, Colin N. A. ;
Risch, Lorenz ;
Scott, Robert A. ;
Scott, Rodney J. ;
Sever, Peter ;
Spector, Tim D. ;
van der Harst, Pim ;
Wareham, Nicholas J. ;
Zeggini, Eleftheria ;
Levy, Daniel ;
Munroe, Patricia B. ;
Newton-Cheh, Christopher ;
Brown, Morris J. ;
Metspalu, Andres ;
Hung, Adriana M. ;
O'Donnell, Christopherj ;
Edwards, Todd L. ;
Psaty, Bruce M. ;
Tzoulaki, Ioanna ;
Barnes, Michael R. ;
Wain, Louise, V ;
Elliott, Paul ;
Caulfield, Mark J.
作者单位：
CNR, Inst Genet & Biomed Res, Natl Res Council, Cagliari, Italy
[1]
Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands
[2]
Univ Edinburgh, Ctr Genom & Expt Med, Inst Genet & Mol Med, Med Genet Sect, Edinburgh, Midlothian
[3]
Brigham & Womens Hosp, Div Prevent Med, 75 Francis St, Boston, MA 02115 USA
[4]
NHLBI, Framingham Heart Study, Framingham, MA USA
[5]
Univ Split, Fac Med, Dept Publ Hlth, Split, Croatia
[6]
Univ Split, Fac Med, Dept Biol, Split, Croatia
[7]
Univ Edinburgh, Ctr Populat Hlth Sci, Usher Inst Populat Hlth Sci & Informat, Edinburgh, Midlothian
[8]
German Res Ctr Environm Hlth, Inst Epidemiol, Helmholtz Zentrum Munchen, Neuherberg, Germany
[9]
Univ Groningen, Univ Med Ctr Groningen, Dept Internal Med, Div Nephrol, Groningen, Netherlands
[10]
Imperial Clin Trials Unit, London, England
[11]
Univ Edinburgh, Usher Inst Populat Hlth Sci & Informat, Edinburgh, Midlothian, Scotland
[12]
McMaster Univ, Dept Pathol & Mol Med, Hamilton, ON, Canada
[13]
Kings Coll London, SGDP Ctr, Inst Psychiat Psychol & Neurosci, London, England
[14]
Univ Texas Hlth Sci Ctr Houston, Human Genet Ctr, Sch Publ Hlth, Houston, TX 77030 USA
[15]
NIA, Lab Cardiovasc Sci, NIH, Baltimore, MD 21224 USA
[16]
Fimlab Labs, Dept Clin Chem, Tampere, Finland
[17]
Univ Washington, Dept Biostat, Seattle, WA 98195 USA
[18]
Vanderbilt Univ, Vanderbilt Epidemiol Ctr, Vanderbilt Genet Inst, Dept Obstet & Gynecol,Med Ctr
[19]
Univ Tartu, Estonian Genome Ctr, Tartu, Estonia
[20]
Newcastle Univ, Inst Genet Med, Newcastle Upon Tyne, Tyne & Wear, England
[21]
Lab Med Zentrum Dr Risch, Schaan, Liechtenstein
[22]
Univ Med Greifswald, Dept Internal Med B, Greifswald, Germany
[23]
CNR, Inst Genet & Biophys A Buzzati Traverso, Naples, Italy
[24]
DZHK German Ctr Cardiovasc Res, Partner Site Greifswald, Greifswald, Germany
[25]
Wellcome Trust Sanger Inst, Hinxton, England
[26]
Univ Groningen, Univ Med Ctr Groningen, Dept Genet, Groningen, Netherlands
[27]
Univ Cambridge, Inst Publ Hlth, Dept Publ Hlth & Primary Care, Cambridge, England
[28]
Univ Med Greifswald, Inst Physiol, Karlsburg, Germany
[29]
Imperial Coll London, MRC PHE Ctr Environm & Hlth, London, England
[30]
Emory Univ, Dept Epidemiol, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA
[31]
NIA, Intramural Res Program, Lab Epidemiol Demog & Biometry, Bethesda, MD 20892 USA
[32]
Sir Charles Gairdner Hosp, Dept Pulm Physiol & Sleep, Hosp Ave, Nedlands, WA, Australia
[33]
Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA
[34]
Royal Coll Surgeons Ireland, Mol & Cellular Therapeut, Dublin, Ireland
[35]
Leiden Univ, Dept Internal Med, Sect Gerontol & Geriatr, Med Ctr, Leiden, Netherlands
[36]
Inst Maternal & Child Hlth IRCCS Burlo Garofolo, Trieste, Italy
[37]
Univ Oxford, Wellcome Ctr Human Genet, Oxford, England
[38]
Univ Trieste, Dept Med Surg & Hlth Sci, Trieste, Italy
[39]
Ist Sci San Raffaele, Div Genet & Cell Biol, Milan, Italy
[40]
Harbor UCLA Med Ctr, Inst Translat Genom & Populat Sci, Dept Pediat, LABioMed, Torrance, CA USA
[41]
Karolinska Inst, Dept Med Solna, Cardiovasc Med Unit, Stockholm, Sweden
[42]
Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England
[43]
Univ Glasgow, Fac Med, Inst Cardiovasc & Med Sci, Glasgow, Lanark, Scotland
[44]
NHGRI, Med Genom & Metab Genet Branch, NIH, Bethesda, MD 20892 USA
[45]
Univ Groningen, Univ Med Ctr Groningen, Dept Psychiat, Groningen, Netherlands
[46]
Univ Dundee, Sch Med, Div Mol & Clin Med, Dundee, Scotland
[47]
Univ Newcastle, Hunter Med Res Inst, New Lambton Hts, NSW, Australia
[48]
Univ Texas Hlth Sci Ctr Houston, Dept Epidemiol Human Genet & Environm Sci, Sch Publ Hlth, Houston
[49]
SPH II, Dept Biostat, Ctr Stat Genet, Ann Arbor, MI USA
[50]
Univ Edinburgh, Ctr Genom & Expt Med, Generat Scotland, Edinburgh, Midlothian, Scotland
[51]
Univ Groningen, Univ Med Ctr Groningen, ICPF, Groningen, Netherlands
[52]
Tampere Univ Hosp, Dept Clin Physiol, Tampere, Finland
[53]
Tennessee Valley Healthcare Syst Nashville VA, Nashville, TN USA
[54]
NIA, Lab Genet & Genom, NIH, Baltimore, MD 21224 USA
[55]
Leiden Univ, Dept Mol Epidemiol, Med Ctr, Leiden, Netherlands
[56]
Data Sci Inst, Lancaster, England
[57]
Dept Publ Hlth & Caring Sci, Geriatr, Uppsala, Sweden
[58]
Stanford Univ, Div Cardiovasc Med, VA Palo Alto Hlth Care Syst, Sch Med, Stanford, CA USA
[59]
Imperial Coll London, Dept Epidemiol & Biostat, London, England
[60]
Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, Groningen, Netherlands
[61]
Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh, Midlothian, Scotland
[62]
Glen Echo, Data Tecn Int, Glen Echo, MD USA
[63]
Vrije Univ Amsterdam Med Ctr, Dept Psychiat, Amsterdam Neurosci, Amsterdam, Netherlands
[64]
Univ Cambridge, MRC Epidemiol Unit, Sch Clin Med, Cambridge, England
[65]
NIH, Ctr Informat Technol, Math & Stat Comp Lab, Off Intramural Res, Bethesda, MD USA
[66]
Univ Lille, Epidemiol & Publ Hlth Dept, RID AGE Risk Factors & Mol Determinants Aging Rel, Inst
[67]
CHU Vaudois, Dept Internal Med, Univ Hosp, Lausanne, Switzerland
[68]
Univ Edinburgh, Ctr Global Hlth Res, Usher Inst Populat Hlth Sci & Informat, Edinburgh, Midlothian
[69]
IMIM, CIBERCV & Cardiovasc Epidemiol & Genet, Barcelona, Spain
[70]
Indian Inst Sci, Ctr Brain Res, Bangalore, Karnataka, India
[71]
Bordeaux Univ Hosp, Dept Neurol, Bordeaux, France
[72]
Queen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, London, England
[73]
Uppsala Univ, Dept Med Sci, Mol Epidemiol & Sci Life Lab, Uppsala, Sweden
[74]
Univ Hosp, Div Cardiol, Basel, Switzerland
[75]
VA Boston Healthcare Syst, Massachusetts Vet Epidemiol Res & Informat Ctr MA, Boston, MA USA
[76]
Memphis VA Med Ctr, Nephrol Sect, Memphis, TN USA
[77]
Vanderbilt Univ, Div Epidemiol, Inst Med & Publ Hlth, Vanderbilt Genet Inst,Med Ctr,Dept Med
[78]
Erasmus MC, Genet Epidemiol Unit, Dept Epidemiol, Rotterdam, Netherlands
[79]
Kings Coll London, Dept Twin Res & Genet Epidemiol, London, England
[80]
Univ Coll Dublin, Sch Med, Dublin, Ireland
[81]
Wake Forest Sch Med, Div Publ Hlth Sci, Winston Salem, NC USA
[82]
Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands
[83]
Univ Eastern Finland, Inst Clin Med, Internal Med, Kuopio, Finland
[84]
Atlanta VAMC, Atlanta, GA USA
[85]
Univ Hosp Lausanne, Inst Social & Prevent Med, Lausanne, Switzerland
[86]
Univ Cambridge, Dept Publ Hlth & Primary Care, MRC BHF Cardiovasc Epidemiol Unit, Cambridge, England
[87]
Columbia Univ, Dept Med, Med Ctr, New York, NY USA
[88]
Univ Leicester, Dept Hlth Sci, Leicester, Leics, England
[89]
Uppsala Univ, Cardiovasc Epidemiol, Dept Med Sci, Uppsala, Sweden
[90]
Imperial Coll London, Int Ctr Circulatory Hlth, London, England
[91]
Vrije Univ Amsterdam Med Ctr, Dept Psychiat, Amsterdam Publ Hlth & Amsterdam Neurosci, GGZ InGeest
[92]
Univ Leicester, Dept Cardiovasc Sci, Leicester, Leics, England
[93]
Lund Univ, Dept Clin Sci, Malmo, Sweden
[94]
Imperial Coll London, Natl Heart & Lung Inst, London, England
[95]
Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA
[96]
New York Acad Med, New York, NY USA
[97]
Broad Inst Harvard & MIT, Program Med & Populat Genet, Cambridge, MA USA
[98]
Med Univ Graz, Dept Neurol, Clin Div Neurogeriatr, Graz, Austria
[99]
Univ Manchester, Fac Biol, Div Cardiovasc Sci, Manchester, Lancs, England
[100]
Univ Helsinki, Inst Mol Med Finland FIMM, Helsinki, Finland
[101]
Dasman Diabet Inst, Kuwait, Kuwait
[102]
German Res Ctr Environm Hlth, Res Unit Mol Epidemiol, Helmholtz Zentrum Munchen, Neuherberg, Germany
[103]
Leiden Univ, Dept Cardiol, Med Ctr, Leiden, Netherlands
[104]
Univ Tartu, Inst Biomed & Translat Med, Tartu, Estonia
[105]
Geneva Univ Hosp, Dept Med, Cardiol, Geneva, Switzerland
[106]
Univ Edinburgh, Dept Psychol, Edinburgh, Midlothian, Scotland
[107]
Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA
[108]
Uppsala Univ, Dept Immunol Genet & Pathol, Sci Life Lab, Uppsala, Sweden
[109]
Eurac Res, Inst Biomed, Bolzano, Italy
[110]
Univ Dundee, Ninewells Hosp & Med Sch, Dundee, Scotland
[111]
Johns Hopkins Univ, Ctr Complex Dis Genom, McKusick Nathans Inst Genet Med, Baltimore, MD USA
[112]
Vrije Univ Amsterdam, Dept Biol Psychol, EMGO Inst, Med Ctr, Amsterdam, Netherlands
[113]
Turku Univ Hosp, Dept Clin Physiol & Nucl Med, Turku, Finland
[114]
Leiden Univ, Dept Clin Epidemiol, Med Ctr, Leiden, Netherlands
[115]
Fujian Med Univ, Fujian Prov Hosp, Dept Geriatr Med, Fujian Key Lab Geriatr, Fuzhou, Fujian
[116]
Univ Iceland, Fac Med, Reykjavik, Iceland
[117]
Natl Inst Hlth & Welf THL, Dept Publ Hlth Solut, Helsinki, Finland
[118]
Univ Edinburgh, Western Gen Hosp, MRC Inst Genet & Mol Med, MRC Human Genet Unit, Edinburgh
[119]
Univ Ioannina, Dept Hyg & Epidemiol, Med Sch, Ioannina, Greece
[120]
Med Univ Graz, Gottfried Schatz Res Ctr Cell Signaling Metab & A, Mol Biol & Biochem, Graz, Austria
[121]
Newcastle Univ, Inst Hlth & Soc, Newcastle Upon Tyne, Tyne & Wear, England
[122]
Massachusetts Gen Hosp, Cardiovasc Res Ctr, Boston, MA 02114 USA
[123]
Univ Bordeaux, Bordeaux Populat Hlth Res Ctr, CHU Bordeaux, Inserm, Bordeaux, France
[124]
Harvard Med Sch, Brigham & Womens Hosp, Sect Cardiol, VA Boston Healthcare, Boston, MA USA
[125]
St Georges Univ London, Populat Hlth Res Inst, London, England
[126]
发布时间
2019-09-19
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Nature Genetics
Nature Genetics
1412-1421页
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