首页> European journal of pharmaceutical sciences> Design, synthesis, biological evaluation and molecular modelling of 2-(2-aryloxyphenyl)-1,4-dihydroisoquinolin-3(2H)-ones: A novel class of TSPO ligands modulating amyloid-beta-induced mPTP opening

Design, synthesis, biological evaluation and molecular modelling of 2-(2-aryloxyphenyl)-1,4-dihydroisoquinolin-3(2H)-ones: A novel class of TSPO ligands modulating amyloid-beta-induced mPTP opening

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第一作者： Elkamhawy, Ahmed

作者： Elkamhawy, Ahmed ^[1] ; Park, Jung-eun ^[2] ; Hassan, Ahmed H. E. ^[3] ; Pae, Ae Nim ^[4] ; Lee, Jiyoun ^[5] ; Park, Beoung-Geon ^[6] ; Paik, Sora ^[7] ; Do, Jimin ^[8] ; Park, Jong-Hyun ; Park, Ki Duk ; Moon, Bongjin ; Park, Woo Kyu ; Cho, Heeyeong ; Jeong, Dae Young ; Roh, Eun Joo

作者单位： Korea Inst Sci & Technol, Chem Kin Res Ctr, Seoul 02792, South Korea ^[1] Sungshin Womens Univ, Dept Global Med Sci, Seoul 142732, South Korea ^[2] Kyung Hee Univ, Coll Pharm, Dept Pharmaceut Sci, Seoul 02447, South Korea ^[3] Korea Inst Sci & Technol, Convergence Res Ctr Diag Treatment & Care Syst De, Seoul 02792, South ^[4] Mansoura Univ, Dept Med Chem, Fac Pharm, Mansoura 35516, Egypt ^[5] Kyung Hee Univ, Dept Pharm, Coll Pharm, Seoul 02447, South Korea ^[6] Korea Res Inst Chem Technol, Div Drug Discovery Res, Daejeon 305343, South Korea ^[7] Sogang Univ, Dept Chem, Seoul 04107, South Korea ^[8]

关键词 Mitochondrial permeability transition pore (mPTP)Retrosynthesis Neurodegenerative diseases Translocator protein (TSPO)beta-amyloid peptide (A beta)Molecular modelling

发布时间 2018-03-07

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