Prediction of oral hepatotoxic dose of natural products derived from traditional Chinese medicines based on SVM classifier and PBPK modeling

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作者： Li, Size ^[1] ; Yu, Yiqun ^[2] ; Bian, Xiaolan ^[3] ; Yao, Li ^[4] ; Li, Min ^[5] ; Lou, Yan-Ru ; Yuan, Jing ; Lin, Hai-shu ; Liu, Lucy ; Han, Bing ; Xiang, Xiaoqiang

作者单位： Fudan Univ, Sch Pharm, Dept Clin Pharm & Pharm Adm, Shanghai 201203, Peoples R China ^[1] Shanghai Jiao Tong Univ, Ruijin Hosp, Dept Pharm, Sch Med, Shanghai 20025, Peoples R China ^[2] Shanghai Qiangshi Informat Technol Co Ltd, Shanghai, Peoples R China ^[3] Fudan Univ, Minhang Hosp, Dept Pharm, Shanghai 201199, Peoples R China ^[4] Shenzhen Technol Univ, Coll Pharm, Shenzhen 518118, Guangdong, Peoples R China ^[5]

关键词 Support vector machine classifier Drug-induced liver injury Natural products derived from traditional Chinese medicines PBPK modeling In vitro to in vivo extrapolation

发布时间 2021-08-04

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