Synthesis, structural characterization, docking, lipophilicity and cytotoxicity of 1-[(1R)-1-(6-fluoro-1,3-benzothiazol-2-yl)ethyl]-3-alkyl carbamates, novel acetylcholinesterase and butyrylcholinesterase pseudo-irreversible inhibitors

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作者： Pejchal, Vladimir ^[1] ; Stepankova, Sarka ^[2] ; Pejchalova, Marcela ^[3] ; Kralovec, Karel ^[4] ; Havelek, Radim ; Ruzickova, Zdenka ; Ajani, Haresh ; Lo, Rabindranath ; Lepsik, Martin

作者单位： Acad Sci Czech Republic, Inst Organ Chem & Biochem Vvi & Giled Sci, Flemingovo Nam 2, Prague 16610 ^[1] Univ Pardubice, Fac Chem Technol, Dept Gen & Inorgan Chem, Studentska 573, Pardubice 53210, Czech ^[2] Univ Pardubice, Fac Chem Technol, Dept Biol & Biochem Sci, Studentska 573, Pardubice 53210, Czech ^[3] Univ Pardubice, Fac Chem Technol, Inst Organ Chem & Technol, Studentska 573, Pardubice 53210, Czech ^[4]

关键词 Halogenated benzothiazole Carbamates Acetylcholinesterase Butyrylcholinesterase inhibition Pseudo-irreversible mechanism Covalent docking

发布时间 2017-04-06

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