Exploring inhibition of Pdx1, a component of the PLP synthase complex of the human malaria parasite Plasmodium falciparum

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作者： Reeksting, Shaun B. ^[1] ; Mueller, Ingrid B. ^[2] ; Burger, Pieter B. ^[3] ; Burgos, Emmanuel S. ^[4] ; Salmon, Laurent ^[5] ; Louw, Abraham I. ; Birkholtz, Lyn-Marie ; Wrenger, Carsten

作者单位： Laboratoire de Chimie Bioorganique et Bioinorganique, CNRS-UMR 8182, Institut de Chimie Moléculaire et des Matériaux d’Orsay, Batiment 420, Université Paris Sud XI, F-91405 Orsay, France ^[1] Biochemistry Department, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York, NY 10461, U.S.A. ^[2] Department of Parasitology, Institute of Biomedical Science, University of So Paulo, Av. Professor Lineu Prestes 1374, 05508-000 So Paulo-SP, Brazil ^[3] Department of Biochemistry, Faculty of Natural and Agricultural Sciences, University of Pretoria, Private Bag X20, Hatfield 0028, South Africa ^[4] Bernhard Nocht Institute for Tropical Medicine, Department of Biochemistry, Bernhard Nocht-Strasse 74, D-20359 Hamburg, Germany ^[5]

关键词 D-erythrose 4-phosphate (E4P)Pdx1 Plasmodium falciparum pyridoxal 5′-phosphate (PLP)PLP synthase vitamin B6

发布时间 2013-11-20

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