2 '-O-(N-(Aminoethyl)carbamoyl)methyl Modification Allows for Lower Phosphorothioate Content in Splice-Switching Oligonucleotides with Retained Activity-论文-万方医学网

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2 '-O-(N-(Aminoethyl)carbamoyl)methyl Modification Allows for Lower Phosphorothioate Content in Splice-Switching Oligonucleotides with Retained Activity

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第一作者： Honcharenko, Dmytro

作者： Honcharenko, Dmytro ^[1] ; Rocha, Cristina S. J. ^[2] ; Lundin, Karin E. ; Maity, Jyotirmoy ; Milton, Stefan ; Tedebark, Ulf ; Murtola, Merita ; Honcharenko, Malgorzata ; Slaitas, Andis ; Smith, C. I. Edvard ; Zain, Rula ; Stromberg, Roger

作者单位： Karolinska Inst ^[1] Syntagon Balt ^[2]

关键词 2 '-O-(N-(aminoethyl)carbamoyl)methyl modification splice-switching oligonucleotides cellular uptake cell-penetrating ONs phosphorothioate linkage oligonucleotide-peptide conjugate ANTISENSE OLIGONUCLEOTIDES CELLULAR UPTAKE IN-VITRO DELIVERY THERAPIES THERAPEUTICS PEPTIDES 2-AMINOADENOSINE HYBRIDIZATION STABILITY

发布时间 2022-08-23

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2 '-O-(N-(Aminoethyl)carbamoyl)methyl Modification Allows for Lower Phosphorothioate Content in Splice-Switching Oligonucleotides with Retained Activity

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2 '-O-(N-(Aminoethyl)carbamoyl)methyl Modification Allows for Lower Phosphorothioate Content in Splice-Switching Oligonucleotides with Retained Activity

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