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Modeling approaches for reducing safety-related attrition in drug discovery and development: a review on myelotoxicity, immunotoxicity, cardiovascular toxicity, and liver toxicity

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作者： Elena M. Tosca ^[1] ; Roberta Bartolucci ; Paolo Magni ; Italo Poggesi

作者单位： Department of Electrical, Computer and Biomedical Engineering, University of Pavia, Pavia, Italy ^[1]

关键词 Safety tolerability attritionrate computational approaches Pharmacokinetic-Pharmacodynamic models quantitative system pharmacology odels hematological toxicity immunotoxicity cardiovascular toxicity drug-induced liver toxicity

发布时间 2023-04-05

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Expert opinion on drug discovery

2021年16卷7/12期

1365-1390页

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Expert opinion on drug discovery

2021年16卷7/12期

1365-1390页

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Modeling approaches for reducing safety-related attrition in drug discovery and development: a review on myelotoxicity, immunotoxicity, cardiovascular toxicity, and liver toxicity

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Modeling approaches for reducing safety-related attrition in drug discovery and development: a review on myelotoxicity, immunotoxicity, cardiovascular toxicity, and liver toxicity

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Expert opinion on drug discovery

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