换一批Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression
作者：
Wray, Naomi R. [1]
;
Ripke, Stephan [2]
;
Mattheisen, Manuel [3]
;
Trzaskowski, Maciej [4]
;
Byrne, Enda M. [5]
;
Abdellaoui, Abdel [6]
;
Adams, Mark J. [7]
;
Agerbo, Esben [8]
;
Air, Tracy M. [9]
;
Andlauer, Till M. F. [10]
;
Bacanu, Silviu-Alin [11]
;
Baekvad-Hansen, Marie [12]
;
Beekman, Aartjan F. T. [13]
;
Bigdeli, Tim B. [14]
;
Binder, Elisabeth B. [15]
;
Blackwood, Douglas R. H. [16]
;
Bryois, Julien [17]
;
Buttenschon, Henriette N. [18]
;
Bybjerg-Grauholm, Jonas [19]
;
Cai, Na [20]
;
Castelao, Enrique [21]
;
Christensen, Jane Hvarregaard [22]
;
Clarke, Toni-Kim [23]
;
Coleman, Jonathan I. R. [24]
;
Colodro-Conde, Lucia [25]
;
Couvy-Duchesne, Baptiste [26]
;
Craddock, Nick [27]
;
Crawford, Gregory E. [28]
;
Crowley, Cheynna A. [29]
;
Dashti, Hassan S. [30]
;
Davies, Gail [31]
;
Deary, Ian J. [32]
;
Degenhardt, Franziska [33]
;
Derks, Eske M. [34]
;
Direk, Nese [35]
;
Dolan, Conor V. [36]
;
Dunn, Erin C. [37]
;
Eley, Thalia C. [38]
;
Eriksson, Nicholas [39]
;
Escott-Price, Valentina [40]
;
Kiadeh, Farnush Hassan Farhadi [41]
;
Finucane, Hilary K. [42]
;
Forstner, Andreas J. [43]
;
Frank, Josef [44]
;
Gaspar, Helena A. [45]
;
Gill, Michael [46]
;
Giusti-Rodriguez, Paola [47]
;
Goes, Fernando S. [48]
;
Gordon, Scott D. [49]
;
Grove, Jakob [50]
;
Hall, Lynsey S. [51]
;
Hannon, Eilis [52]
;
Hansen, Christine Soholm [53]
;
Hansen, Thomas F. [54]
;
Herms, Stefan [55]
;
Hickie, Ian B. [56]
;
Hoffmann, Per [57]
;
Homuth, Georg [58]
;
Horn, Carsten [59]
;
Hottenga, Jouke-Jan [60]
;
Hougaard, David M. [61]
;
Hu, Ming [62]
;
Hyde, Craig L. [63]
;
Ising, Marcus [64]
;
Jansen, Rick [65]
;
Jin, Fulai [66]
;
Jorgenson, Eric [67]
;
Knowles, James A. [68]
;
Kohane, Isaac S. [69]
;
Kraft, Julia [70]
;
Kretzschmar, Warren W. [71]
;
Krogh, Jesper [72]
;
Kutalik, Zoltan [73]
;
Lane, Jacqueline M. [74]
;
Li, Yihan [75]
;
Li, Yun [76]
;
Lind, Penelope A. [77]
;
Liu, Xiaoxiao [78]
;
Lu, Leina [79]
;
MacIntyre, Donald J. [80]
;
MacKinnon, Dean F. [81]
;
Maier, Robert M. [82]
;
Maier, Wolfgang [83]
;
Marchini, Jonathan [84]
;
Mbarek, Hamdi [85]
;
McGrath, Patrick [86]
;
McGuffin, Peter [87]
;
Medland, Sarah E. [88]
;
Mehta, Divya [89]
;
Middeldorp, Christel M. [90]
;
Mihailov, Evelin [91]
;
Milaneschi, Yuri [92]
;
Milani, Lili [93]
;
Mill, Jonathan [94]
;
Mondimore, Francis M. [95]
;
Montgomery, Grant W. [96]
;
Mostafavi, Sara [97]
;
Mullins, Niamh [98]
;
Nauck, Matthias ;
Ng, Bernard ;
Nivard, Michel G. ;
Nyholt, Dale R. ;
O'Reilly, Paul F. ;
Oskarsson, Hogni ;
Owen, Michael J. ;
Painter, Jodie N. ;
Pedersen, Carsten Bocker ;
Pedersen, Marianne Giortz ;
Peterson, Roseann E. ;
Pettersson, Erik ;
Peyrot, Wouter J. ;
Pistis, Giorgio ;
Posthuma, Danielle ;
Purcell, Shaun M. ;
Quiroz, Jorge A. ;
Qvist, Per ;
Rice, John P. ;
Riley, Brien P. ;
Rivera, Margarita ;
Mirza, Saira Saeed ;
Saxena, Richa ;
Schoevers, Robert ;
Schulte, Eva C. ;
Shen, Ling ;
Shi, Jianxin ;
Shyn, Stanley I. ;
Sigurdsson, Engilbert ;
Sinnamon, Grant B. C. ;
Smit, Johannes H. ;
Smith, Daniel J. ;
Stefansson, Hreinn ;
Steinberg, Stacy ;
Stockmeier, Craig A. ;
Streit, Fabian ;
Strohmaier, Jana ;
Tansey, Katherine E. ;
Teismann, Henning ;
Teumer, Alexander ;
Thompson, Wesley ;
Thomson, Pippa A. ;
Thorgeirsson, Thorgeir E. ;
Tian, Chao ;
Traylor, Matthew ;
Treutlein, Jens ;
Trubetskoy, Vassily ;
Uitterlinden, Andre G. ;
Umbricht, Daniel ;
Van der Auwera, Sandra ;
van Hemert, Albert M. ;
Viktorin, Alexander ;
Visscher, Peter M. ;
Wang, Yunpeng ;
Webb, Bradley T. ;
Weinsheimer, Shantel Marie ;
Wellmann, Juegen ;
Willemsen, Gonneke ;
Witt, Stephanie H. ;
Wu, Yang ;
Xi, Hualin S. ;
Yang, Jian ;
Zhang, Futao ;
Arolt, Volker ;
Baune, Bernhard T. ;
Berger, Klaus ;
Boomsma, Dorret I. ;
Cichon, Sven ;
Dannlowski, Udo ;
de Geus, E. C. J. ;
DePaulo, J. Raymond ;
Domenici, Enrico ;
Domschke, Katharina ;
Esko, Tonu ;
Grabe, Hans J. ;
Hamilton, Steven P. ;
Hayward, Caroline ;
Heath, Andrew C. ;
Hinds, David A. ;
Kendler, Kenneth S. ;
Kloiber, Stefan ;
Lewis, Glyn ;
Li, Qingqin S. ;
Lucae, Susanne ;
Madden, Pamela F. A. ;
Magnusson, Patrik K. ;
Martin, Nicholas G. ;
McIntosh, Andrew M. ;
Metspalu, Andres ;
Mors, Ole ;
Mortensen, Preben Bo ;
Mueller-Myhsok, Bertram ;
Nordentoft, Merete ;
Noethen, Markus M. ;
O'Donovan, Michael C. ;
Paciga, Sara A. ;
Pedersen, Nancy L. ;
Penninx, Brenda W. J. H. ;
Perlis, Roy H. ;
Porteous, David J. ;
Potash, James B. ;
Preisig, Martin ;
Rietschel, Marcella ;
Schaefer, Catherine ;
Schulze, Thomas G. ;
Smoller, Jordan W. ;
Stefansson, Kari ;
Tiemeier, Henning ;
Uher, Rudolf ;
Voelzke, Henry ;
Weissman, Myrna M. ;
Werge, Thomas ;
Winslow, Ashley R. ;
Lewis, Cathryn M. ;
Levinson, Douglas F. ;
Breen, Gerome ;
Borglum, Anders D. ;
Sullivan, Patrick F.
作者单位：
Kaiser Permanente Northern Calif, Div Res, Oakland, CA USA
[1]
Univ Queensland, Inst Mol Biosci, Brisbane, Qld, Australia
[2]
Univ Southern Calif, Psychiat & Behav Sci, Los Angeles, CA USA
[3]
Pfizer Global Res & Dev, Computat Sci Ctr Emphasis, Cambridge, MA USA
[4]
Cardiff Univ, Psychol Med, Cardiff, S Glam, Wales
[5]
Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA
[6]
23andMe Inc, Res, Mountain View, CA USA
[7]
Univ Sydney, Brain & Mind Ctr, Sydney, NSW, Australia
[8]
Univ Hosp Lausanne, Dept Psychiat, Prilly, Switzerland
[9]
Univ Med, Dept Funct Gen, Interfac Inst Genet & Funct Gen, Greifswald, Germany
[10]
Johns Hopkins Univ, Psychiat & Behav Sci, Baltimore, MD USA
[11]
Univ Tartu, Estonian Genome Ctr, Tartu, Estonia
[12]
Univ British Columbia, Med Genet, Vancouver, BC, Canada
[13]
Erasmus MC, Internal Med, Rotterdam, Netherlands
[14]
Aarhus Univ, Ctr Integrat Sequencing, iSEQ, Aarhus, Denmark
[15]
Boston Childrens Hosp, Informat Program, Boston, MA USA
[16]
Univ Munster, Dept Psychiat, Munster, Germany
[17]
Vrije Univ Amsterdam, Dept Biol Psychol, Amsterdam, Netherlands
[18]
Univ Mississippi, Med Ctr, Psychiat & Human Behav, Jackson, MS 39216 USA
[19]
Columbia Univ, Coll Phys & Surg, Psychiat, New York, NY USA
[20]
Janssen Res & Dev LLC, Neurosci Therapeut Area, Titusville, NJ USA
[21]
Kings Coll London, MRC Social Genet & Dev Psychiat, London, England
[22]
Univ Trento, Ctr Integrat Biol, Trento, Italy
[23]
Solid Biosci, Boston, MA USA
[24]
Univ Adelaide, Discipline Psychiat, Adelaide, SA, Australia
[25]
Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USA
[26]
QIMR Berghofer Med Res Inst, Genet & Computat Biol, Herston, Qld, Australia
[27]
F Hoffmann La Roche Ltd, Roche Innovat Ctr Basel, Ophthalmol & Rare Dis Discovery & Translat Med Ar
[28]
Brigham & Womens Hosp, Dept Psychiat, 75 Francis St, Boston, MA 02115 USA
[29]
Univ British Columbia, Bioinformat, Vancouver, BC, Canada
[30]
Univ Med Greifswald, Inst Community Med, Greifswald, Germany
[31]
Univ Bonn, Dept Psychiat & Psychotherapy, Bonn, Germany
[32]
Humus, Reykjavik, Iceland
[33]
F Hoffmann La Roche Ltd, Roche Innovat Ctr Basel, Roche Pharmaceut Res & Early Dev Pharmaceut Sci
[34]
Case Western Reserve Univ, Case Comprehens Canc Ctr, Cleveland, OH 44106 USA
[35]
Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England
[36]
Univ Groningen, Univ Med Ctr Groningen, Dept Psychiat, Groningen, Netherlands
[37]
Swiss Inst Bioinformat, Lausanne, Switzerland
[38]
Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden
[39]
Univ Glasgow, Inst Hlth & Wellbeing, Glasgow, Lanark, Scotland
[40]
Broad Inst, Med & Populat Genet, Cambridge, MA USA
[41]
Broad Inst, Stanley Ctr Psychiat Res, Cambridge, MA USA
[42]
Univ Freiburg, Fac Med, Med Ctr, Dept Psychiat & Psychotherapy, Freiburg, Germany
[43]
Erasmus MC, Epidemiol, Rotterdam, Netherlands
[44]
Univ Edinburgh, Div Psychiat, Edinburgh, Midlothian, Scotland
[45]
Kaiser Permanente Washington, Behavioral Hlth Serv, Seattle, WA USA
[46]
Cleveland Clin, Quantitat Hlth Sci, Cleveland, OH USA
[47]
Univ N Carolina, Biostat, Chapel Hill, NC USA
[48]
UCL, Div Psychiat, London, England
[49]
Cardiff Univ, Coll Biomed & Life Sci, Cardiff, S Glam, Wales
[50]
Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh, Midlothian, Scotland
[51]
Rigshosp, Dept Neurol, Danish Headache Ctr, Glostrup, Denmark
[52]
Univ British Columbia, Stat, Vancouver, BC, Canada
[53]
Lundbeck Fdn Initiat Integrat Psychiat Res, iPSYCH, Aarhus, Denmark
[54]
Aarhus Univ, Dept Biomed, Aarhus, Denmark
[55]
Univ Cambridge, Clin Neurosci, Cambridge, England
[56]
deCODE Genet Amgen Inc, Reykjavik, Iceland
[57]
NHS 24, Mental Hlth, Glasgow, Lanark, Scotland
[58]
Univ Exeter, Med Sch, Exeter, Devon, England
[59]
Univ Med Greifswald, Univ Med, DZHK German Ctr Cardiovasc Res, Partner Site Greifswald, Greifswald
[60]
Max Planck Inst Chem, Munich, Germany
[61]
Kaiser Permanente Northern Calif, Psychiat, San Francisco, CA USA
[62]
Univ Edinburgh, IGMM, CGEM, Med Genet Sect, Edinburgh, Midlothian, Scotland
[63]
Univ Munster, Inst Epidemiol & Social Med, Munster, Germany
[64]
Univ Med Greifswald, Dept Psychiat & Psychotherapy, Greifswald, Germany
[65]
Univ Edinburgh, Inst Genet & Mol Med, MRC Human Genet Unit, Edinburgh, Midlothian, Scotland
[66]
Univ Med Berlin, Campus Charite Mitte, Dept Psychiat & Psychothe, Berlin, Germany
[67]
Case Western Reserve Univ, Dept Genet & Genome Sci, Cleveland, OH 44106 USA
[68]
Cardiff Univ, Neurosci & Mental Hlth, Cardiff, S Glam, Wales
[69]
Queensland Univ Technol, Inst Hlth & Biomed Innovat, Brisbane, Qld, Australia
[70]
Univ Iceland, Dept Psychiat, Fac Med, Reykjavik, Iceland
[71]
Pfizer Global Res & Dev, Human Genet & Computat Biomed, Groton, CT USA
[72]
Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia
[73]
Cardiff Univ, MRC Ctr Neuropsychiat Genet & Genom, Cardiff, S Glam, Wales
[74]
Leiden Univ, Med Ctr, Dept Psychiat, Leiden, Netherlands
[75]
European Bioinformat Inst EMBL EBI, Stat Genom & Syst Genet, Cambridge, England
[76]
Trin Coll Dublin, Dept Psychiat, Dublin, Ireland
[77]
Univ Bonn, Inst Human Genet, Bonn, Germany
[78]
Univ Oxford, Stat, Oxford, England
[79]
Virginia Commonwealth Univ, Dept Psychiat, Richmond, VA USA
[80]
Pfizer Global Res & Dev, Human Genet & Computat Biomed, Cambridge, MA USA
[81]
Virginia Commonwealth Univ, Virginia Inst Psychiat & Behav Genet, Richmond, VA USA
[82]
Dalhousie Univ, Psychiat, Halifax, NS, Canada
[83]
Univ Munich, Med Ctr, Dept Psychiat & Psychotherapy, Campus Innenstadt, Munich, Germany
[84]
Washington Univ, Sch Med, Dept Psychiat, St Louis, MO USA
[85]
Pfizer Global Res & Dev, Stat, Groton, CT USA
[86]
Univ Copenhagen, Herlev Univ Hosp, Dept Endocrinol, Copenhagen, Denmark
[87]
James Cook Univ, Sch Med & Dent, Townsville, Qld, Australia
[88]
Max Planck Inst Psychiat, Dept Translat Res Psychiat, Munich, Germany
[89]
Natl Canc Inst, Div Canc Epidemiol & Genet, Bethesda, MD USA
[90]
QIMR Berghofer Med Res Inst, Genet & Computat Biol, Brisbane, Qld, Australia
[91]
Vrije Univ, Med Ctr, Dept Psychiat, Amsterdam, Netherlands
[92]
Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Genet Epidemiol Psychiat, Mannheim
[93]
Dokuz Eylul Univ, Sch Med, Psychiat, Izmir, Turkey
[94]
Vrije Univ Amsterdam, Complex Trait Genet, Amsterdam, Netherlands
[95]
Stanford Univ, Psychiat & Behav Sci, Stanford, CA USA
[96]
Duke Univ, Ctr Genom & Computat Biol, Durham, NC USA
[97]
Univ N Carolina, Genet, Chapel Hill, NC USA
[98]
发布时间
2018-12-20
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Nature Genetics
Nature Genetics
668-681页
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