The development of a structurally distinct series of BACE1 inhibitors via the ( Z )-fluoro-olefin amide bioisosteric replacement

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作者： Frohn, Michael ^[1] ; Liu, Longbin ^[2] ; Siegmund, Aaron C. ^[3] ; Qian, Wenyuan ^[4] ; Amegadzie, Albert ^[5] ; Chen, Ning ; Tan, Helming ; Hickman, Dean ; Wood, Stephen ; Wen, Paul H. ; Bartberger, Michael D. ; Whittington, Douglas A. ; Allen, Jennifer R. ; Bourbeau, Matthew P.

作者单位： Amgen Inc, Amgen Discovery Res, Neurosci Res, Thousand Oaks, CA 91320 USA ^[1] Amgen Inc, Amgen Discovery Res, Pharmicokinet & Drug Metab, Thousand Oaks, CA 91320 USA ^[2] Amgen Inc, Amgen Discovery Res, Mol Engn, Thousand Oaks, CA 91320 USA ^[3] Amgen Inc, Amgen Discovery Res, Prepivotal Drug Prod, Thousand Oaks, CA 91320 USA ^[4] Amgen Inc, Amgen Discovery Res, Med Chem, Thousand Oaks, CA 91320 USA ^[5]

发布时间 2020-10-12

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