Design, synthesis, in vitro and in vivo biological evaluation of 2-amino-3-aroylbenzo[b]furan derivatives as highly potent tubulin polymerization inhibitors-论文-万方医学网

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Design, synthesis, in vitro and in vivo biological evaluation of 2-amino-3-aroylbenzo[b]furan derivatives as highly potent tubulin polymerization inhibitors

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第一作者： Oliva, Paola

作者： Oliva, Paola ^[1] ; Romagnoli, Romeo ^[2] ; Manfredini, Stefano ^[3] ; Brancale, Andrea ^[4] ; Ferla, Salvatore ^[5] ; Hamel, Ernest ^[6] ; Ronca, Roberto ; Maccarinelli, Federica ; Giacomini, Arianna ; Rruga, Fatlum ; Mariotto, Elena ; Viola, Giampietro ; Bortolozzi, Roberta

作者单位： Univ Padua, Lab Oncoematol, Dipartimento Salute Donna & Bambino, I-35131 Padua, Italy ^[1] Univ Ferrara, Dipartimento Sci Chim & Farmaceut, Via Luigi Borsari 46, I-44121 Ferrara, Italy ^[2] Univ Ferrara, Dept Life Sci & Biotechnol, Via Fossato Mortara 17-19, I-44121 Ferrara, Italy ^[3] Cardiff Univ, Sch Pharm & Pharmaceut Sci, King Edward VII Ave, Cardiff CF10 3NB, Wales ^[4] NCI, Screening Technol Branch, Dev Therapeut Program,NIH, Div Canc Treatment & Diag,Frederick Natl ^[5] Univ Brescia, Dipartimento Med Mol & Traslaz, Unita Oncol Sperimentale Immunol, I-25123 Brescia ^[6]

关键词 Microtubules Benzo[b]furan In vivo activity Inhibition tubulin assembly Colchicine binding site

发布时间 2022-09-10

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Design, synthesis, in vitro and in vivo biological evaluation of 2-amino-3-aroylbenzo[b]furan derivatives as highly potent tubulin polymerization inhibitors

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Design, synthesis, in vitro and in vivo biological evaluation of 2-amino-3-aroylbenzo[b]furan derivatives as highly potent tubulin polymerization inhibitors

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