Incorporating a Genetic Risk Score Into Coronary Heart Disease Risk Estimates Effect on Low-Density Lipoprotein Cholesterol Levels (the MI-GENES Clinical Trial)

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作者： Kullo, Iftikhar J. ^[1] ; Jouni, Hayan ^[2] ; Austin, Erin E. ^[3] ; Brown, Sherry-Ann ^[4] ; Kruisselbrink, Teresa M. ^[5] ; Isseh, Iyad N. ; Haddad, Raad A. ; Marroush, Tariq S. ; Shameer, Khader ; Olson, Janet E. ; Broeckel, Ulrich ; Green, Robert C. ; Schaid, Daniel J. ; Montori, Victor M. ; Bailey, Kent R.

作者单位： Mayo Clin, Dept Med, Div Cardiovasc Dis, Rochester, MN 55905 USA ^[1] Brigham & Womens Hosp, Dept Med, Div Genet, 75 Francis St, Boston, MA 02115 USA ^[2] Mayo Clin, Dept Hlth Sci Res, Rochester, MN 55905 USA ^[3] Med Coll Wisconsin, Dept Pediat Med & Physiol, Milwaukee, WI 53226 USA ^[4] Mayo Clin, Knowledge & Evaluat Res Unit, Rochester, MN 55905 USA ^[5]

关键词 genetic risk score coronary disease genetic risk disclosure genomics hydroxymethylglutaryl-CoA reductase inhibitors prevention & control randomized clinical trials polymorphism single-nucleotide

发布时间 2017-04-05

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