首页> Journal of Medicinal Chemistry> Discovery of 1-{(3R,4R)-3[({5-Chloro-2-[(1-methyl-1H-pyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)methyl]-4-methoxypyrrolidin-1-yl}prop-2-en-1-one (PF-06459988), a Potent, WT Sparing, Irreversible Inhibitor of T790M-Containing EGFR Mutants

Discovery of 1-{(3R,4R)-3[({5-Chloro-2-[(1-methyl-1H-pyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)methyl]-4-methoxypyrrolidin-1-yl}prop-2-en-1-one (PF-06459988), a Potent, WT Sparing, Irreversible Inhibitor of T790M-Containing EGFR Mutants

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第一作者： Cheng, Hengmiao

作者： Cheng, Hengmiao ^[1] ; Nair, Sajiv K. ^[1] ; Murray, Brion W. ^[1] ; Almaden, Chau ^[1] ; Bailey, Simon ^[1] ; Baxi, Sangita ^[1] ; Behenna, Doug ^[1] ; Cho-Schultz, Sujin ^[2] ; Dalvie, Deepak ^[1] ; Dinh, Dac M. ^[1] ; Edwards, Martin P. ^[2] ; Feng, Jun Li ^[1] ; Ferre, Rose Ann ^[1] ; Gajiwala, Ketan S. ^[1] ; Hemkens, Michelle D. ^[1] ; Jackson-Fisher, Amy ^[1] ; Jalaie, Mehran ^[1] ; Johnson, Ted O. ^[1] ; Kania, Robert S. ^[1] ; Kephart, Susan ^[1] ; Lafontaine, Jennifer ^[1] ; Lunney, Beth ^[1] ; Liu, Kevin K-C. ^[1] ; Liu, Zhengyu ^[1] ; Matthews, Jean ^[1] ; Nagata, Asako ^[1] ; Niessen, Sherry ^[1] ; Ornelas, Martha A. ^[1] ; Orr, Suvi T. M. ^[1] ; Pairish, Mason ^[1] ; Planken, Simon ^[1] ; Ren, Shijian ^[1] ; Richter, Daniel ^[1] ; Ryan, Kevin ^[1] ; Sach, Neal ^[1] ; Shen, Hong ^[1] ; Smeal, Tod ^[1] ; Solowiej, Jim ^[1] ; Sutton, Scott ^[1] ; Tran, Khanh ^[1] ; Tseng, Elaine ^[1] ; Vemier, William ^[1] ; Walls, Marlena ^[1] ; Wang, Shuiwang ^[1] ; Weinrich, Scott L. ^[1] ; Xin, Shuibo ^[1] ; Xu, Haiwei ^[2] ; Yin, Min-Jean ^[1] ; Zientek, Michael ^[1] ; Zhou, Ru ^[1] ; Kath, John C.

作者单位： Pfizer Worldwide Res & Dev, La Jolla Labs, 10770 Sci Ctr Dr, San Diego, CA 92121 USA ^[1] Wuxi AppTec, 288 Fute Zhong Rd, Shanghai 200131, Peoples R China ^[2]

发布时间 2017-04-05

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