Genomic Subtypes of Non-invasive Bladder Cancer with Distinct Metabolic Profile and Female Gender Bias in KDM6A Mutation Frequency

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作者： Carolyn D. Hurst ^[1] ; Olivia Alder ^[2] ; Fiona M. Platt ^[3] ; Alastair Droop ^[4] ; Lucy F. Stead ^[5] ; Julie E. Burns ^[6] ; George J. Burghel ^[7] ; Sunjay Jain ^[8] ; Leszek J. Klimczak ^[9] ; Helen Lindsay ^[10] ; Jo-An Roulson ^[11] ; Claire F. Taylor ; Helene Thygesen ; Angus J. Cameron ; Anne J. Ridley ; Helen R. Mott ; Dmitry A. Gordenin ; Margaret A. Knowles

作者单位： Pyrah Department of Urology, St James's University Hospital ^[1] Department of Histopathology, St James's University Hospital ^[2] Barts Cancer Institute, Queen Mary University of London ^[3] Section of Brain Tumour Research, Leeds Institute of Cancer and Pathology, St James's University ^[4] Randall Division of Cell and Molecular Biophysics, New Hunt's House, King's College London, Guy's ^[5] Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health ^[6] Section of Molecular Oncology, Leeds Institute of Cancer and Pathology, St James's University ^[7] Department of Biochemistry, University of Cambridge ^[8] DNA Laboratory, Genetics Service, Ashley Wing, St James University Hospital ^[9] Integrative Bioinformatics Support Group, National Institute of Environmental Health Sciences, NIH ^[10] Cancer Research UK Leeds Centre, Leeds Institute of Cancer and Pathology, St James's University ^[11]

关键词 bladder cancer genomics subtypes recurrence-free survival mTORC1 metabolism gender KDM6A RHOB

发布时间 2019-04-17

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