作者单位:Columbia Univ Coll Phys & Surg, Dept Neurol, New York, NY 10032 USA[1]Washington Univ, Sch Med, Dept Med, Div Endocrinol Metab & Lipid Res, St Louis, MO 63110 USA[2]Tokyo Med Univ, Dept Mol Pathol, Tokyo 1608402, Japan[3]Washington Univ, Sch Med, Dept Neurol, St Louis, MO 63110 USA[4]