Discovery of Novel, Potent, Brain-Permeable, and Orally Efficacious Positive Allosteric Modulator of alpha 7 Nicotinic Acetylcholine Receptor [4-(5-(4-Chlorophenyl)-4-methyl-2-propionylthiophen-3-yl)benzenesulfonamide]: Structure-Activity Relationship and Preclinical Characterization

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作者： Sinha, Neelima ^[1] ; Karche, Navnath P. ; Verma, Mahip Kalyan ; Walunj, Sameer S. ; Nigade, Prashant B. ; Jana, Gourhari ; Kurhade, Sanjay P. ; Hajare, Anil K. ; Tilekar, Ajay R. ; Jadhav, Ganesh R. ; Thube, Baban R. ; Shaikh, Javed S. ; Balgude, Sudhakar ; Singh, Lairikyengbam Bikramjit ; Mahimane, Vijaya ; Adurkar, Shridhar K. ; Hatnapure, Girish ; Raje, Firoj ; Bhosale, Yogesh ; Bhanage, Dnyaneshwar ; Sachchidanand, Sachchidanand ; Dixit, Ruchi ; Gupta, Rajesh ; Bokare, Anand M. ; Dandekar, Manoj ; Bharne, Ashish ; Chatterjee, Manavi ; Desai, Sagar ; Koul, Sarita ; Modi, Dipak ; Mehta, Maneesh ; Patil, Vinod ; Singh, Minakshi ; Gundu, Jayasagar ; Goel, Rajan N. ; Shah, Chirag ; Sharma, Sharad ; Bakhle, Dhananjay ; Kamboj, Rajender Kumar ; Palle, Venkata P.

作者单位： Lupin Ltd, Lupin Res Pk, Novel Drug Discovery & Dev, Survey 46 A-47 A, Pune 412115, Maharashtra, India ^[1]

发布时间 2021-09-26

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Journal of Medicinal Chemistry

2020年63卷3期

944-960页

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Discovery of Novel, Potent, Brain-Permeable, and Orally Efficacious Positive Allosteric Modulator of alpha 7 Nicotinic Acetylcholine Receptor [4-(5-(4-Chlorophenyl)-4-methyl-2-propionylthiophen-3-yl)benzenesulfonamide]: Structure-Activity Relationship and Preclinical Characterization

Journal of Medicinal Chemistry

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Discovery of Novel, Potent, Brain-Permeable, and Orally Efficacious Positive Allosteric Modulator of alpha 7 Nicotinic Acetylcholine Receptor [4-(5-(4-Chlorophenyl)-4-methyl-2-propionylthiophen-3-yl)benzenesulfonamide]: Structure-Activity Relationship and Preclinical Characterization

Journal of Medicinal Chemistry

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Journal of Medicinal Chemistry

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