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Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: A genome-wide association study

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第一作者: Naj,A.C.
作者: Naj,A.C. [1] ; Jun,G. [2] ; Reitz,C. [3] ; Kunkle,B.W. [4] ; Perry,W. [5] ; Park,Y.S. [6] ; Beecham,G.W. [7] ; Rajbhandary,R.A. [8] ; Hamilton-Nelson,K.L. [9] ; Wang,L.-S. [10] ; Kauwe,J.S.K. [11] ; Huentelman,M.J. [12] ; Myers,A.J. [13] ; Bird,T.D. [14] ; Boeve,B.F. [15] ; Baldwin,C.T. [16] ; Jarvik,G.P. [17] ; Crane,P.K. [18] ; Rogaeva,E. [19] ; Barmada,M.M. [20] ; Demirci,F.Y. [21] ; Cruchaga,C. [22] ; Kramer,P.L. [23] ; Ertekin-Taner,N. [24] ; Hardy,J. [25] ; Graff-Radford,N.R. [26] ; Green,R.C. [27] ; Larson,E.B. [28] ; St.George-Hyslop,P.H. [29] ; Buxbaum,J.D. [30] ; Evans,D.A. [31] ; Schneider,J.A. [32] ; Lunetta,K.L. [33] ; Kamboh,M.I. [34] ; Saykin,A.J. [35] ; Reiman,E.M. [36] ; DeJager,P.L. [37] ; Bennett,D.A. [38] ; Morris,J.C. [39] ; Montine,T.J. [40] ; Goate,A.M. [41] ; Blacker,D. [42] ; Tsuang,D.W. [43] ; Hakonarson,H. [44] ; Kukull,W.A. [45] ; Foroud,T.M. [46] ; Martin,E.R. [47] ; Haines,J.L. [48] ; Mayeux,R.P. [49] ; Farrer,L.A. [50] ; Schellenberg,G.D. [51] ; Pericak-Vance,M.A. [52] ; Albert,M.S. [53] ; Albin,R.L. [54] ; Apostolova,L.G. [55] ; Arnold,S.E. [56] ; Barber,R. [57] ; Barnes,L.L. [58] ; Beach,T.G. [59] ; Becker,J.T. [60] ; Beekly,D. [61] ; Bigio,E.H. [62] ; Bowen,J.D. [63] ; Boxer,A. [64] ; Burke,J.R. [65] ; Cairns,N.J. [66] ; Cantwell,L.B. [67] ; Cao,C. [68] ; Carlson,C.S. [69] ; Carney,R.M. [70] ; Carrasquillo,M.M. [71] ; Carroll,S.L. [72] ; Chui,H.C. [73] ; Clark,D.G. [74] ; Corneveaux,J. [75] ; Cribbs,D.H. [76] ; Crocco,E.A. [77] ; DeCarli,C. [78] ; DeKosky,S.T. [79] ; Dick,M. [80] ; Dickson,D.W. [81] ; Duara,R. [82] ; Faber,K.M. [83] ; Fallon,K.B. [84] ; Farlow,M.R. [85] ; Ferris,S. [86] ; Frosch,M.P. [87] ; Galasko,D.R. [88] ; Ganguli,M. ; Gearing,M. ; Geschwind,D.H. ; Ghetti,B. ; Gilbert,J.R. ; Glass,J.D. ; Growdon,J.H. ; Hamilton,R.L. ; Harrell,L.E. ; Head,E. ; Honig,L.S. ; Hulette,C.M. ; Hyman,B.T. ; Jicha,G.A. ; Jin,L.-W. ; Karydas,A. ; Kaye,J.A. ; Kim,R. ; Koo,E.H. ; Kowall,N.W. ; Kramer,J.H. ; LaFerla,F.M. ; Lah,J.J. ; Leverenz,J.B. ; Levey,A.I. ; Li,G. ; Lieberman,A.P. ; Lin,C.-F. ; Lopez,O.L. ; Lyketsos,C.G. ; Mack,W.J. ; Martiniuk,F. ; Mash,D.C. ; Masliah,E. ; McCormick,W.C. ; McCurry,S.M. ; McDavid,A.N. ; McKee,A.C.
作者单位: Department of Pathology and Laboratory Medicine, Emory UniversityAtlanta, GA, United States, Emory [1] Department of Neurosciences, University of California San DiegoSan Diego, United States, Department [2] Department of Neurology, Oregon Health and Science UniversityPortland, United States, Department of [3] Department of Neurobiology and Behavior, University of California IrvineIrvine, United States [4] Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of [5] Neurogenetics Program, University of California Los AngelesLos Angeles, United States [6] Department of Neurological Sciences, Rush University Medical CenterChicago, IL, United States, Rush [7] Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia [8] Institute for the Neurosciences, Department of Neurology and Psychiatry, Brigham and Women's [9] Swedish Medical CenterSeattle, WA, United States [10] Department of Neuroscience, Mount Sinai School of MedicineNew York, NY, United States, Department [11] Department of Neurology, Johns Hopkins UniversityBaltimore, MD, United States [12] Group Health Research Institute, Group Health CooperativeSeattle, WA, United States [13] Rush Institute for Healthy Aging, Department of Internal Medicine, Rush University Medical [14] Department of Neuroscience, Mayo ClinicJacksonville, FL, United States [15] Department of Medicine, Duke UniversityDurham, NC, United States [16] Department of Medicine - Pulmonary, New York UniversityNew York, United States [17] Department of Neurology, Indiana UniversityIndianapolis, United States [18] Genetics Program, Department of Medicine, Boston UniversityBoston, MA, United States, Department of [19] Department of Psychiatry, School of Medicine, Washington University in St LouisSt Louis, MO, United [20] Department of Psychiatry, University of PittsburghPittsburgh, PA, United States [21] Department of Neurology, Mayo ClinicJacksonville, FL, United States, Institute of Neurology [22] Department of Medical and Molecular Genetics, Indiana UniversityIndianapolis, United States [23] Dr. John T. Macdonald Foundation Department of Human Genetics, University of MiamiMiami, FL, United [24] Department of Neurosciences, University of California San DiegoSan Diego, United States [25] Department of Neurology, Emory UniversityAtlanta, GA, United States [26] Department of Pathology, University Of MichiganAnn Arbor, United States [27] Department of Psychiatry, University of Pennsylvania, Perelman School of MedicinePhiladelphia [28] Department of Epidemiology, Harvard School of Public HealthBoston, MA, United States, Department of [29] Department of Neurology, University of California IrvineIrvine, United States [30] Division of Genetics, Department of Medicine, Brigham and Women's HospitalBoston, MA, United States [31] Department of Neurology, Washington University in St LouisSt Louis, MO, United States [32] Department of Neurology, Boston UniversityBoston, MA, United States, Department of Pathology [33] Departments of Psychiatry, Neurology, and Psychology, University of Pittsburgh School of [34] Department of Biology, Brigham Young UniversityProvo, UT, United States [35] Department of Pathology, University of Alabama at BirminghamBirmingham, United States [36] Department of Pathology, Northwestern University, Feinberg School of MedicineChicago, IL, United [37] Neurogenomics Division, Translational Genomics Research InstitutePhoenix, AZ, United States [38] Civin Laboratory for Neuropathology, Banner Sun Health Research InstitutePhoenix, AZ, United States [39] Wien Center for Alzheimer's Disease and Memory Disorders, Mount Sinai Medical CenterMiami Beach, FL [40] Tanz Centre for Research in Neurodegenerative Disease, University of TorontoToronto, ON, Canada [41] USF Health Byrd Alzheimer's Institute, University of South FloridaTampa, United States [42] Institute for Memory Impairments and Neurological Disorders, University of California IrvineIrvine [43] University of Virginia School of MedicineCharlottesville, United States [44] Department of Preventive Medicine, University of Southern CaliforniaLos Angeles, United States [45] Department of Pharmacology and Neuroscience, University of North Texas Health Science CenterFort [46] Department of Neurological Sciences, Rush University Medical CenterChicago, IL, United States [47] Department of Molecular Physiology and Biophysics, Vanderbilt UniversityNashville, TN, United [48] Department of Genome Sciences, University of WashingtonSeattle, United States, Division of Medical [49] Department of Pathology, University of WashingtonSeattle, United States [50] Gertrude H. Sergievsky Center, Columbia UniversityNew York, NY, United States, Department of [51] Department of Pathology and Laboratory Medicine, University of Pennsylvania, Perelman School of [52] Department of Epidemiology, Boston UniversityBoston, MA, United States [53] Sanders-Brown Center on Aging, Department Neurology, University of KentuckyLexington, United States [54] Department of Human Genetics, University of PittsburghPittsburgh, PA, United States [55] Department of Human Genetics, University of PittsburghPittsburgh, PA, United States, Alheimer [56] Department of Pathology and Immunology, Washington University in St LouisSt Louis, MO, United [57] Department of Neurology, University of California DavisSacramento, United States [58] Geriatric Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care [59] John P. Hussman Institute for Human Genomics, University of Miami, Biomedical Research Bldg, 1501 [60] Department of Neurology, Massachusetts General Hospital, Harvard Medical SchoolBoston, United States [61] Department of Neurology, University of California San FranciscoSan Francisco, United States [62] Department of Psychiatry, New York UniversityNew York, United States [63] Department of Biostatistics, Boston UniversityBoston, MA, United States [64] Alheimer Disease Research Center, University of PittsburghPittsburgh, PA, United States [65] National Alzheimer's Coordinating Center, University of WashingtonSeattle, United States [66] Department of Pathologyand Laboratory Medicine, Indiana UniversityIndianapolis, United States [67] Department of Psychiatry, Johns Hopkins UniversityBaltimore, MD, United States [68] C.S. Kubik Laboratory for Neuropathology, Massachusetts General HospitalCharlestown, United States [69] Department of Neurology, University of MiamiMiami, FL, United States [70] Department of Neurology, Oregon Health and Science UniversityPortland, United States [71] Department of Pathology and Laboratory Medicine, University of California DavisSacramento, United [72] Department of Epidemiology, University of WashingtonSeattle, United States [73] Department of Neurology, University of California Los AngelesLos Angeles, United States [74] Department of Neurology, University of WashingtonSeattle, United States, Geriatric Research [75] Department of Neurology, University of MichiganAnn Arbor, United States, Geriatric Research [76] Department of Neurology, University of Southern CaliforniaLos Angeles, United States [77] Department of Pathology, Duke UniversityDurham, NC, United States [78] Center for Applied Genomics, Children's Hospital of PhiladelphiaPhiladelphia, PA, United States [79] Department of Neurology, Mayo ClinicRochester, MN, United States [80] Sanders-Brown Center on Aging, Department of Molecular and Biomedical Pharmacology, University of [81] Department of Psychiatry and Behavioral Sciences, University of Washington, School of [82] Department of Biostatistics and Epidemiology, University of Pennsylvania, Perelman School of [83] Fred Hutchinson Cancer Research CenterSeattle, WA, United States [84] Department of Epidemiology, Boston UniversityBoston, MA, United States, Department of Pathology [85] Department of Neurology, University of Alabama at BirminghamBirmingham, United States [86] Department of Epidemiology, Boston UniversityBoston, MA, United States, School of Nursing Northwest [87] Department of Pathology and Laboratory Medicine, University of California IrvineIrvine, United [88]
发布时间 2015-03-10
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