A novel diclofenac-hydrogel conjugate system for intraarticular sustained release: Development of 2-pyridylamino-substituted 1-phenylethanol (PAPE) and its derivatives as tunable traceless linkers-论文-万方医学网

A novel diclofenac-hydrogel conjugate system for intraarticular sustained release: Development of 2-pyridylamino-substituted 1-phenylethanol (PAPE) and its derivatives as tunable traceless linkers

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作者： Kawanami, Toshio ^[1] ; LaBonte, Laura R. ^[2] ; Amin, Jakal ^[3] ; Thibodeaux, Stefan J. ; Lee, Cameron C. ; Argintaru, O. Andreea ; Adams, Christopher M.

作者单位： Novartis Inst BioMed Res, Global Discovery Chem, 100 Technol Sq, Cambridge, MA 02139 USA ^[1] Novartis Inst BioMed Res, Pharmacokinet Sci, 250 Massachusetts Ave, Cambridge, MA 02139 USA ^[2] Novartis Inst BioMed Res, Analyt Sci & Imaging, 250 Massachusetts Ave, Cambridge, MA 02139 USA ^[3]

关键词 Diclofenac Osteoarthritis Hydrogel 2-Pyridylamino substituted 1-phenylethanol (PAPE)Polymeric prodrug Drug delivery system Sustained release

发布时间 2022-09-10

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