Discovery of 2,6-difluorobenzyl ether series of phenyl ((R)-3-phenylpyrrolidin-3-yl)sulfones as surprisingly potent, selective and orally bioavailable ROR gamma t inverse agonists-论文-万方医学网

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Discovery of 2,6-difluorobenzyl ether series of phenyl ((R)-3-phenylpyrrolidin-3-yl)sulfones as surprisingly potent, selective and orally bioavailable ROR gamma t inverse agonists

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第一作者： Duan, James J-W

作者： Duan, James J-W ^[1] ; Jiang, Bin ; Lu, Zhonghui ; Stachura, Sylwia ; Weigelt, Carolyn A. ; Sack, John S. ; Khan, Javed ; Ruzanov, Max ; Wu, Dauh-Rurng ; Yarde, Melissa ; Shen, Ding-Ren ; Zhao, Qihong ; Salter-Cid, Luisa M. ; Carter, Percy H. ; Dhar, T. G. Murali

作者单位： Bristol Myers Squibb Co, Res & Early Dev, Princeton, NJ 08543 USA ^[1]

关键词 ROR gamma t Inverse agonist Pyrrolidinyl sulfone Difluorobenzyl ether

发布时间 2021-03-06

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Discovery of 2,6-difluorobenzyl ether series of phenyl ((R)-3-phenylpyrrolidin-3-yl)sulfones as surprisingly potent, selective and orally bioavailable ROR gamma t inverse agonists

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Discovery of 2,6-difluorobenzyl ether series of phenyl ((R)-3-phenylpyrrolidin-3-yl)sulfones as surprisingly potent, selective and orally bioavailable ROR gamma t inverse agonists

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