Entry of therapeutics into the brain: Influence of exposed polarity calculated in silico and measured in vitro by supercritical fluid chromatography

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作者： Russo, Giacomo ^[1] ; Barbato, Francesco ^[2] ; Grumetto, Lucia ^[3] ; Philippe, Laurence ; Lynen, Frederic ; Goetz, Gilles H.

作者单位： Univ Ghent, Dept Organ & Macromol Chem, Separat Sci Grp, Krijgslaan 281,S4 Bis, B-9000 Ghent ^[1] Univ Naples Federico II, Sch Med & Surg, Pharm Anal & Biopharm Lab, Dept Pharm, Via D Montesano 49 ^[2] Pfizer Global Res & Dev, Worldwide Med Chem, Groton Labs, Eastern Point Rd, Groton, CT 06340 USA ^[3]

关键词 EPSA Supercritical fluid chromatography Immobilized artificial membranes Blood-brain barrier Accessible surface area

发布时间 2019-09-20

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International Journal of Pharmaceutics

2019年560卷

294-305页

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Entry of therapeutics into the brain: Influence of exposed polarity calculated in silico and measured in vitro by supercritical fluid chromatography

International Journal of Pharmaceutics

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International Journal of Pharmaceutics

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Entry of therapeutics into the brain: Influence of exposed polarity calculated in silico and measured in vitro by supercritical fluid chromatography

International Journal of Pharmaceutics

相似文献

International Journal of Pharmaceutics

相关期刊

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