Design and Evaluation of Highly Selective Human Immunoproteasome Inhibitors Reveal a Compensatory Process That Preserves Immune Cell Viability

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作者： Ladi, Ena ^[1] ; Everett, Christine ^[2] ; Stivala, Craig E. ^[2] ; Daniels, Blake E. ^[3] ; Durk, Matthew R. ^[3] ; Harris, Seth F. ^[4] ; Huestis, Malcolm P. ^[3] ; Purkey, Hans E. ^[3] ; Staben, Steven T. ^[5] ; Augustin, Martin ^[3] ; Blaesse, Michael ^[6] ; Steinbacher, Stefan ^[3] ; Eidenschenk, Celine ^[4] ; Pappu, Rajita ^[2] ; Siu, Michael ^[1]

作者单位： Genentech Inc, Dept Biochem & Cellular Pharmacol, 1 DNA Way, San Francisco, CA 94080 USA ^[1] Proteros Biostruct GmbH, Bunsenstr 7a, D-82152 Planegg Martinsried, Germany ^[2] Genentech Inc, Dept Discovery Chem, 1 DNA Way, San Francisco, CA 94080 USA ^[3] Genentech Inc, Dept Immunol, 1 DNA Way, San Francisco, CA 94080 USA ^[4] Genentech Inc, Dept Drug Metab & Pharmacokinet, 1 DNA Way, San Francisco, CA 94080 USA ^[5] Genentech Inc, Dept Struct Biol, 1 DNA Way, San Francisco, CA 94080 USA ^[6]

发布时间 2020-02-11

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Journal of Medicinal Chemistry

2019年62卷15期

7032-7041页

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Design and Evaluation of Highly Selective Human Immunoproteasome Inhibitors Reveal a Compensatory Process That Preserves Immune Cell Viability

Journal of Medicinal Chemistry

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Journal of Medicinal Chemistry

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Design and Evaluation of Highly Selective Human Immunoproteasome Inhibitors Reveal a Compensatory Process That Preserves Immune Cell Viability

Journal of Medicinal Chemistry

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Journal of Medicinal Chemistry

相关期刊

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