Discovery of 5-Phenyl-N-(pyridin-2-ylmethyl)-2-(pyrimidin-5-yl)quinazolin-4-amine as a Potent I-Kur Inhibitor

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作者： Finlay, Heather J. ^[1] ; Johnson, James A. ^[2] ; Lloyd, John L. ^[3] ; Jiang, Ji ^[4] ; Neels, James ^[2] ; Gunaga, Prashantha ^[2] ; Baneriee, Abhisek ^[3] ; Dhondi, Naveen ^[3] ; Chimalakonda, Anjaneya ^[3] ; Mandlekar, Sandhya ^[3] ; Conder, Mary Lee ^[5] ; Sale, Hatinath ^[4] ; Xing, Dezhi ^[3] ; Levesque, Paul ^[1] ; Wexler, Ruth R. ^[4]

作者单位： Biocon Bristol Myers Squibb Res Ctr BBRC, Dept Preclin Candidate Optimizat, Bangalore 560099, Karnataka, India ^[1] Biocon Bristol Myers Squibb Res Ctr BBRC, Dept Discovery Chem, Bangalore 560099, Karnataka, India ^[2] Bristol Myers Squibb Co, Res & Dev, Dept Discovery Chem, POB 5400, Princeton, NJ 08543 USA ^[3] Bristol Myers Squibb Co, Res & Dev, Dept Biol, POB 5400, Princeton, NJ 08543 USA ^[4] Bristol Myers Squibb Co, Res & Dev, Dept Preclin Candidate Optimizat, POB 5400, Princeton, NJ 08543 USA ^[5]

关键词 K-v 1.5 phenylquinazoline ventricular effective refractory period atrial effective refractory period

发布时间 2017-04-06

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