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A randomized, double-blind, placebo-controlled, phase 2b Study to evaluate the safety and efficacy of recombinant human soluble thrombomodulin, ART-123, in patients with sepsis and suspected disseminated intravascular coagulation

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作者: Vincent,J.-L. [1] ; Ramesh,M.K. [2] ; Ernest,D. [3] ; Larosa,S.P. [4] ; Pachl,J. [5] ; Aikawa,N. [6] ; Hoste,E. [7] ; Levy,H. [8] ; Hirman,J. [9] ; Levi,M. [10] ; Daga,M. [11] ; Kutsogiannis,D.J. [12] ; Crowther,M. [13] ; Bernard,G.R. [14] ; Devriendt,J. [15] ; Puigserver,J.V. [16] ; Blanzaco,D.U. [17] ; Esmon,C.T. [18] ; Parrillo,J.E. [19] ; Guzzi,L. [20] ; Henderson,S.J. [21] ; Pothirat,C. [22] ; Mehta,P. [23] ; Fareed,J. [24] ; Talwar,D. [25] ; Tsuruta,K. [26] ; Gorelick,K.J. [27] ; Osawa,Y. ; Kaul,I.
作者单位: Howard Levy Consulting LLC, Hopewell, NJ, United States [1] Metro Hospitals, Noida, India [2] Servei d'Urgències, Hospital Universitari Son Espases, Palma de Mallorca, Spain [3] Department of Intensive Care, CHU Brugmann, Brussels, Belgium [4] Oklahoma Medical Research Foundation, Howard Hughes Medical Institute, Oklahoma City, OK, United [5] Zymo Consulting Group LLC, Newtown Square, PA, United States [6] Mehta Hospital and Cardiopulmonary Care Centre, Ahmedabad, India [7] Department of Medicine, Vanderbilt University, Nashville, TN, United States [8] Department of Medicine, Monash University, Monash Medical Center, Clayton, VIC, Australia [9] Pacific Northwest Statistical Consulting, Woodinville, WA, United States [10] Division of Infectious Disease, Beverly Hospital/Lahey Health, Beverly, MA, United States [11] Asahi Kasei Pharma America Corporation, Waltham, MA, United States [12] Division of Pulmonary and Critical Care, Faculty of Medicine, Chiang Mai University, Chiang Mai [13] Department of Anesthesiology and Critical Care Medicine, Charles University Prague, Faculty [14] Heart and Vascular Hospital, Hackensack University Medical Center, New Jersey Medical School of [15] Department of Intensive Care, Hospital San Martín, Paraná, Argentina [16] Department of Medicine, McMaster University and St Joseph's Hospital, Hamilton, Canada [17] Department of Emergency and Critical Care Medicine, School of Medicine, Keio University, Shinjukuku [18] Department of Intensive Care, Erasme Hospital, Université Libre de Bruxelles, Brussels, Belgium [19] Florida Hospital, Orlando, FL, United States [20] Pathology and Pharmacology, Loyola University Medical Center, Maywood, IL, United States [21] Division of Critical Care Medicine, Faculty of Medicine and Dentistry, University of Alberta [22] Department of Vascular Medicine and Internal Medicine, Academic Medical Center, Amsterdam [23] Department of Intensive Care, Christchurch Hospital, Christchurch, New Zealand [24] Department of Intensive Care Medicine, Ghent University Hospital, Ghent University, Ghent, Belgium [25] Department of Medicine, Maulana Azad Medical College, New Delhi, India [26] Department of Surgery, Victoria Hospital, Bangalore Medical College and Research Institute [27]
发布时间 2013-11-20
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