The functional role of the alpha M4 transmembrane helix in the muscle nicotinic acetylcholine receptor probed through mutagenesis and coevolutionary analyses
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关键词
nicotinic acetylcholine receptor (nAChR)pentameric ligand-gated ion channel (pLGIC)lipid-protein interactionsM4 transmembrane helixtransmembrane domainchannel gatingGLICELIClipid sensingmembrane proteincoevolutionary analysisCys-loop receptormutagenesisprotein evolutionM4X-RAY-STRUCTUREALLOSTERIC MODULATIONCYS-LOOPTRYPTOPHAN SUBSTITUTIONSMOLECULAR-DYNAMICSAROMATIC RESIDUESLIPID-COMPOSITIONION-CHANNELC-TERMINUS
发布时间
2022-05-28
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