S6K1 inhibition enhances tamoxifen-induced cell death in MCF-7 cells through translational inhibition of Mcl-1 and survivin

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作者： Hong, Sung-Eun ^[1] ; Kim, Eun-Kyu ^[2] ; Jin, Hyeon-Ok ^[3] ; Kim, Hyun-Ah ^[4] ; Lee, Jin Kyung ^[5] ; Koh, Jae Soo ; Seol, Hyesil ; Kim, Jong-Il ; Park, In-Chul ; Noh, Woo Chul

作者单位： Department of Surgery, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, 215-4 Gongneung-dong, Nowon-gu, Seoul, 139-706, Republic of Korea ^[1] Division of Radiation Cancer Research, Korea Institute of Radiological and Medical Sciences, 215-4 Gongneung-dong, Nowon-gu, Seoul, 139-706, Republic of Korea ^[2] Department of Laboratory Medicine, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, 215-4 Gongneung-dong, Nowon-gu, Seoul, 139-709, Republic of Korea ^[3] Department of Food and Microbial Technology, Seoul Women’s University, 126 Gongneung-dong, Nowon-gu, Seoul, 139-774, Republic of Korea ^[4] Department of Pathology, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, 215-4 Gongneung-dong, Nowon-gu, Seoul, 139-706, Republic of Korea ^[5]

关键词 Endocrine therapy resistance Mammalian target of rapamycin PF4708671 S6 kinase 1 Tamoxifen

发布时间 2013-12-29

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