Snapshots of Iron Speciation: Tracking the Fate of Iron Nanoparticle Drugs via a Liquid Chromatography-Inductively Coupled Plasma-Mass Spectrometric Approach

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作者： Neu, Heather M. ^[1] ; Alexishin, Sergei A. ^[2] ; Brandis, Joel E. P. ^[3] ; Williams, Anne M. C. ^[4] ; Li, Wenjing ; Sun, Dajun ; Zheng, Nan ; Jiang, Wenlei ; Zimrin, Ann ; Fink, Jeffrey C. ; Polli, James E. ; Kane, Maureen A. ; Michel, Sarah L. J.

作者单位： Univ Maryland, Sch Pharm, Dept Pharmaceut Sci, Baltimore, MD 21201 USA ^[1] US FDA, Off Res & Stand, Off Gener Drugs, Ctr Drug Evaluat & Res, Silver Spring, MD 20993 USA ^[2] Univ Maryland, Oncol Program, Sch Med, Baltimore, MD 21201 USA ^[3] Univ Maryland, Sch Med, Dept Med, Baltimore, MD 21201 USA ^[4]

关键词 liquid chromatography-inductively coupled plasma-mass spectrometry sodium ferric gluconate drug-bound iron nanomedicine labile iron nontransferrin-bound iron protein bound iron metal speciation complex nonbiological drug

发布时间 2019-10-16

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