Recombinant human lecithin-cholesterol acyltransferase Fc fusion: Analysis of N- and O-linked glycans and identification and elimination of a xylose-based O-linked tetrasaccharide core in the linker region

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作者： Spahr,C. ^[1] ; Kim,J.J. ^[2] ; Deng,S. ^[3] ; Kodama,P. ^[4] ; Xia,Z. ^[5] ; Tang,J. ; Zhang,R. ; Siu,S. ; Nuanmanee,N. ; Estes,B. ; Stevens,J. ; Zhou,M. ; Lu,H.S.

作者单位： Protein Technologies, Therapeutic Discovery, Amgen Inc., South San Francisco, CA 94080, United ^[1] Drug Substance Development, Amgen Inc., Seattle, WA 98119, United States ^[2] Metabolic Disorders, Amgen Inc., South San Francisco, CA 94080, United States ^[3] Biologics Optimization, Therapeutic Discovery, Amgen Inc., Seattle, WA 98119, United States ^[4] Biologics Optimization, Therapeutic Discovery, Amgen Inc., 1 Amgen Center Drive, Thousand Oaks, CA ^[5]

关键词 N-and O-linked glycans Recombinant human LCAT-Fc Site-specific N-linked glycan profile Xylose-based glycosaminoglycan

发布时间 2018-10-31

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