Evaluation of drug-induced neurotoxicity based on metabolomics, proteomics and electrical activity measurements in complementary CNS in vitro models

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作者： Schultz, Luise ^[1] ; Zurich, Marie-Gabrielle ^[2] ; Culot, Maxime ^[3] ; da Costa, Anaelle ^[4] ; Landry, Christophe ^[5] ; Bellwon, Patricia ^[6] ; Kristl, Theresa ^[7] ; Hoermann, Katrin ^[8] ; Ruzek, Silke ; Aiche, Stephan ; Reinert, Knut ; Bielow, Chris ; Gosselet, Fabien ; Cecchelli, Romeo ; Huber, Christian G. ; Schroeder, Olaf H. -U. ; Gramowski-Voss, Alexandra ; Weiss, Dieter G. ; Bal-Price, Anna

作者单位： Free Univ Berlin, Dept Math & Comp Sci, D-14195 Berlin, Germany ^[1] NeuroProof GmbH, D-18119 Rostock, Germany ^[2] Univ Artois, LBHE EA2465, Fac Jean Perrin, F-62307 Lens, France ^[3] Paris Lodron Univ, Dept Mol Biol, Salzburg, Austria ^[4] Univ Wurzburg, Dept Toxicol, D-97078 Wurzburg, Germany ^[5] Univ Rostock, Dept Anim Physiol, Inst Biol Sci, D-18051 Rostock, Germany ^[6] Inst Hlth & Consumer Protect, European Commiss Joint Res Ctr, I-21027 Ispra, VA, Italy ^[7] Univ Lausanne, Dept Physiol, Fac Biol & Med, Lausanne, Switzerland ^[8]

关键词 In vitro blood brain barrier MEA Neuronal network culture OMICs Drug development 3D brain culture

发布时间 2020-05-08

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